The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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The Clinical Role of $^{99m}Tc$-(V)-DMSA Imaging in Patients with Head and Neck Cancer

두경부 종양에서 $^{99m}Tc$-(V)-DMSA 영상술의 진단적 유용성

  • Bae, Sun-Kun (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Lee, Jae-Tae (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Park, June-Sik (Department of Otorhinolaryngology, Kyungpook National University Hospital) ;
  • Park, In-Kyu (Department of Radiation Oncology, Kyungpook National University Hospital) ;
  • Hyun, Dong-Woo (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Lee, Young-Hak (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Kim, Jeong-Gyun (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Ahn, Byeong-Cheal (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Choi, Ji-Yong (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Sohn, Sang-Gyun (Department of Nuclear Medicine, Kyungpook National University Hospital) ;
  • Lee, Kyu-Bo (Department of Nuclear Medicine, Kyungpook National University Hospital)
  • 배선근 (경북대학교병원 핵의학과) ;
  • 이재태 (경북대학교병원 핵의학과) ;
  • 박준식 (경북대학교병원 이비인후과) ;
  • 박인규 (경북대학교병원 치료방사선과) ;
  • 현동우 (경북대학교병원 핵의학과) ;
  • 이영학 (경북대학교병원 핵의학과) ;
  • 김정균 (경북대학교병원 핵의학과) ;
  • 안병철 (경북대학교병원 핵의학과) ;
  • 최지용 (경북대학교병원 핵의학과) ;
  • 손상균 (경북대학교병원 핵의학과) ;
  • 이규보 (경북대학교병원 핵의학과)
  • Published : 1995.12.25
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Abstract

Introduction : $^{99m}Tc$-(V)-DMSA is a tumor seeking agent that has been used to image medullary carcinoma of thyroid, soft tissue sarcoma and lung cancer. This study was designed to assess the clinical role of $^{99m}Tc$-(V)-DMSA in the diagnosis of head and neck cancers. We has evaluated the diagnostic efficacy of planar and SPECT imaging using $^{99m}Tc$-(V)-DMSA. Patients and Method : Sixty-eight patients with head and neck mass were included in this study. All subjects were diagnosed by biopsy or surgery. Planar and SPECT images were obtained at 2 or 3 hour after intravenous injection of 740 MBq(20 mCi) $^{99m}Tc$-(V)-DMSA. Seventeen patients also underwent SPECT in aging using dual head camera. Result : The diagnostic sensitivity of $^{99m}Tc$-(V)-DMSA planar and SPECT imaging was 65% and 90%, and specificity was 80% and 66%, respectively. The sensitivity of planar imaging in squamous cell carcinoma was similar to overall sensitivity Six metastatic lesion were first diagnosed by scintigraphy. But benign lesions such as Kikuchi syndrome, tuberculous lymphadenitis also revealed increased uptake. Conclusion : $^{99m}Tc$-(V)-DMSA imaging seems to be a promising method in the evaluation of patients with head and neck mass. We recommend SPECT imaging to delineate anatomic localization of the lesion.

두경부의 악성 종양의 진단에서 $^{99m}Tc$-(V)-DMSA 영상술은 비교적 높은 양성율을 보여 주었고 (Planar 65%, SPECT 90%), 원격 전이부위의 영상진단에도 도움이 되었다. 그러나 $^{99m}Tc$-(V)-DMSA는 두경부의 양성 병변에도 섭취가 될 수 있어, 판독 시 임상검사 및 다른 영상소견과의 비교검토가 필요할 것으로 판단된다.

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