The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Determination of Brain Death by $^{99m}Tc$ DTPA and $^{99m}Tc$ HMPAO Images

$^{99m}Tc$ DTPA와 $^{99m}Tc$ HMPAO를 이용한 뇌사결정

  • Kim, Jong-Kyu (Department of Radiology, Catholic University Medical College) ;
  • Sohn, Hyung-Sun (Department of Radiology, Catholic University Medical College) ;
  • Kim, Sung-Hoon (Department of Radiology, Catholic University Medical College) ;
  • Yang, Woo-Jin (Department of Radiology, Catholic University Medical College) ;
  • Lee, Sung-Yong (Department of Radiology, Catholic University Medical College) ;
  • Chung, Soo-Kyo (Department of Radiology, Catholic University Medical College) ;
  • Park, Seog-Hee (Department of Radiology, Catholic University Medical College) ;
  • Kim, Choon-Yul (Department of Radiology, Catholic University Medical College) ;
  • Bahk, Yong-Whee (Department of Radiology, Catholic University Medical College) ;
  • Shinn, Kyung-Sub (Department of Radiology, Catholic University Medical College)
  • 김종규 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 손형선 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 김성훈 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 양우진 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 이성용 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 정수교 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 박석희 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 김춘열 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 박용휘 (가톨릭대학교 의과대학 방사선과학교실) ;
  • 신강섭 (가톨릭대학교 의과대학 방사선과학교실)
  • Published : 1995.03.31
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Abstract

To evaluate availability of cerebral radionuclide imaging for diagnosis of brain death, we examined 25 patients with a suspected clinical diagnosis of brain death. 8 patients were studied by $^{99m}Tc$ DTPA and 15 patients were studied by $^{99m}Tc$ HMPAO (Hexamethyl propyleneamine oxime). Seven patients with $^{99m}Tc$ DTPA studies revealed absence of cerebral blood flow and sagittal sinus activity. All of 15 patients with $^{99m}Tc$ HMPAO studies revealed complete absence of cerebral perfusion. The results of the cerebral radionuclide studies of brain death correlated with other clinical conditions, such as intracranial pressure(ICP), EEG, transcranial doppler sonography(TCDS), and neurologic examination. The ICP of 8 patients, who are confirmed by brain death with $^{99m}Tc$ HMPAO study are elevated in all cases. In conclusion, cerebral radionuclide imaging for diagnosis of brain death is available. $^{99m}Tc$ HMPAO imaging is unequivocal, easily interpreted, well reflect the physiologic state of increased ICP, and provides adequate assessment of posterior fossa activity. In addition, the SPECT imaging with $^{99m}Tc$ HMPAO produces more accurate results due to it's superiority of image contrast and proper localization of radiopharmaceutical distribution than conventional planar imaging.

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