Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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A Study on the Chemical Constituents from Marine Sponge Luffariella sp.

해면 Luffariella sp.의 화학적 성분 연구

  • Park, Sun Ku (Youngsan River Water Resource Inspection Center National Institute of Environmental Research) ;
  • Kim, Sung Soo (Youngsan River Water Resource Inspection Center National Institute of Environmental Research) ;
  • Park, Jun Dae (Youngsan River Water Resource Inspection Center National Institute of Environmental Research) ;
  • Hong, Jung Sun (Youngsan River Water Resource Inspection Center National Institute of Environmental Research) ;
  • Kim, In Kyu (Department of Chemistry, Sung Kyun Kwan University)
  • 박선구 (국립환경연구원 영산강수질검사소) ;
  • 김성수 (국립환경연구원 영산강수질검사소) ;
  • 박준대 (국립환경연구원 영산강수질검사소) ;
  • 홍정선 (국립환경연구원 영산강수질검사소) ;
  • 김인규 (성균관대학교 화학과)
  • Published : 19950700
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Abstract

The three metabolites, Germacrene alcohol(1), Aaptamine(2) and Hexacyclic terpene(3) were isolated from Marine Sponge Luffariella sp., collected in October 1992, Manado Bay, Sulawesi in Indonesia showed in vitro activity against KB cancer cell line, and structure assignment for 1 was corrected by comparison of their spectral data with the literature $values^1$. Their structure were elucidated by $^1H$, $^13C$ NMR, $^1H$ $^13C$(1 bond) Heteronuclear Multiple Quantum Coherence Spectroscopy$(HMQC)^2$, $^1H$ $^13C$(2 and 3 bond) Heteronuclear Multiple Bond Correlation Spectroscopy$(HMBC)^3$, Electron Impact Mass Spectroscopy(EI ms), Ultra-violet Spectroscopy(UV) and Infrared Spectroscopy(IR).

인도네시아 Manado만의 Sulawesi에서 채집한 KB cancer cell line에 대해 in vitro로 활성을 갖는 해면 Luffariella sp.으로부터 Germacrene alcohol(1), Aaptamine(2) 및 Hexacyclic terpene(3)을 분리하였으며, 1에대한 spectral data는 문헌치와 비교${\cdot}$분석하여 수정하였다. 이들을 $^1H$, $^13C$ NMR, $^1H$ $^13C$(bond) Heteronuclear Multiple Quantum Coherence Spectroscopy(HMQC), $^1H$$^13C$(2 and 3 bond)Heteronuclear Multiple Bond Correlation Spectroscopy(HMBC), Electron Impact Mass Spectroscopy(EI ms), UV 및 IR에 의해 밝혔다.

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References

  1. Tetrahedron v.38 Izac, R. R.;Bandurraga, M. M.;Wasylyk, J. M.;Dunn, F. W.;Fenical, W.
  2. J. Magn. Reson. v.76 Ottig, G.;Wuthrich, K.
  3. J. Am. Chem. Soc. v.108 Bax, A.;Summers, M. F.
  4. Bioorganic Marine Chemistry v.3 Scheuer, P. J.
  5. J. Am. Chem. Soc. v.108 Zabriskie, T. M.;Klocke, J. A.;Ireland, C. M.;Molinski, T. F.;Faulkner, D. J.;Xu, C.;Clardy, J. C.
  6. Biochemistry v.117 Cook, K. M.;Friedberg, E. C.
  7. J. Chem. Soc. Perkin Trans. Ⅰ Nakamura, H.;Kobayashi, J.;Ohizumi, Y.
  8. Tetrahedron Letters v.23 Nakamura, H.;Kobayashi, J.;Ohizumi, Y.
  9. Experientia v.45 Kernan, M. R.;Faulkner, D. J.;Parkanyi, L.;Clardy, J.;de Carvalho, M. S.;Jacobs, R. S.