Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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The Chemical Constituents from the Sponge Spongia sp.

해면 Spongia sp.의 화학적 성분 연구

  • Park, Sun-Ku (Youngsan River Water Resource Research Institute, National Institute of Environmental Research) ;
  • Oh, Chang-Sok (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Scheuer, Paul-J. (Department of Chemistry, University of Hawaii at Manoa)
  • 박선구 (국립환경연구원 영산강수질검사소) ;
  • 오창석 (한국과학기술연구원 응용과학부) ;
  • Published : 19950400
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Abstract

The cytotoxic metabolites, against the KB cell line, halenaquinone, epispongiatriol and aldisin were isolated from the sponge Spongia sp. collected in September 1992, Manado Bay, Sulawesi in Indonesia. Their structures were elucidated by 1H, 13C NMR, 1H 13C(1 bond) Heteronuclear Multiple Quantum Coherence Spectroscopy (HMQC), 1H 13C(2 and 3 bond) Heteronuclear Multiple Bond Correlation Spectroscopy (HMBC), Electron Impact Mass Spectroscopy (EI ms) and Infrared Spectroscopy (IR).

인도네시아 Manado만의 Sulawesi에서 채집한 해면 Spongia sp.로부터 KB Cancer cell line에 대하여 활성을 갖는 halenaquinone, epispongiatriol 및 aldisin을 분리하였다. 이들의 구조를 $1^H,\;13^C\;NMR\;1^H\;13^C(1\;bond)$ Heteronuclear Multiple Quantum Coherence Spectroscopy (HMQC), 1H 13C(2 and 3 bond) Heteronuclear Multiple Bond Correlation Spectroscopy (HMBC), Electron Impact Mass Spectroscopy (EI ms) 및 IR로 밝혔다.

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References

  1. J. Magn. Reson. v.76 Ottig, G.;Wuthrich, K.
  2. J. Am. Chem. Soc. v.108 Bax, A.;Summers, M. F.
  3. Bioorganic Marine Chemistry v.3 Scheuer, P. J.
  4. J. Am. Chem. Soc. v.108 Zabriskie, T. M.;Klocke, J. A.;Ireland, C. M.;Marcus, A. H.;Molinski, T. F.;Faulkner, D. J.;Xu, C.;Clardy, J. C.
  5. Biochemistry v.17 Cook, K. M.;Friedberg, E. C.
  6. J. Am. Chem. Soc. v.105 Roll. D. M.;Scheuer, P. J.;Matsumoto, G. K.;Clardy, J.
  7. Chemistry Letters Nakamura, H.;Kobayashi, J.;Kobayashi, M.;Ohizumi, Y.;Hirata, Y.
  8. Chem. Pharm. Bull. Kobayashi, M.;Shimizu, N.;Kyogoku, Y.;Kitagawa, I.
  9. J. Exp. Biol. Med. Sci. v.60 Marwood, J. F.
  10. Aust. J. Chem. v.32 Kazalauskas, R.;Murphym, P. T.;Wells, R. J.;Noack, K.;Oberhansli, W.;Schonhalzer, P.
  11. J. Nat. Prod. v.48 Schmitz, F. J.;Gunasekera, S.P.;Lakshmi, V.;Tillekeratne, L. M.