Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Substituent Effects on the Reactivity of the Pyridines$^{1,2}$

  • Published : 1995.07.20
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Abstract

The relative dissociation constants of 4-substituted bicyclo[2,2,2]octane-1-carboxylic acids, 4-substituted quinuclidines, and 3-and 4-substituted pyridines were collected from a number of sources. In order to understand the actual substituent effects with a combination of inductive effect (σI) and resonance effect (σR) components. The DSP correlation has been employed statistically for each of the p-and m-series. The inductive effect from the m-position was 1.2 times more effective than that from the p-position and the requirement of σR+ for the best-fit led to the conclusion that pyridine system belongs to the σ+-class reactivity. Also compared with results from Yukawa-Tsuno's LArSR treatment and relevant treatment.

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References

  1. This research is in part supported by the Korea Science and Engineering Foundation (921-0300-032-2), and the Basic Research Instituted Program, Ministry of Education, Korea (BSRI-94-3402)
  2. Ph.D degree, Graduated School of the Kyungpook Nat. Univ. D. Y. Cheong
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