Biomolecules & Therapeutics
- Volume 3 Issue 1
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- Pages.54-57
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- 1995
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
The Effect of Ruthenium Red on the Capsaicin-Induced Antinociception in vivo
- Lee, Bu-Yean (Korea Research Institute of Chemical Technology) ;
- Jung, Yi-Sook (Korea Research Institute of Chemical Technology) ;
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Choi, Jin-Il
(Korea Research Institute of Chemical Technology) ;
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Kong, Jae-Yang
(Korea Research Institute of Chemical Technology)
- Published : 1995.03.01
Abstract
The effect of Ruthenium Red on the antinociceptive action of capsaicinoids was investigated using tail-flick test in mice. Capsaicin and KR-25018, when administered subcutaneously, had a potent antinociceptive effect against noxious heat stimulus. Ruthenium Red which is known to block the calcium channel coupled to the capsaicin receptor, when injected intraperitoneally more than 5 mg/kg, showed severe sedation and apparent antinociceptive effect against noxious heat stimulus. The 2.5 mg/kg Ruthenium Red, at which dose any significant sedative effect was not shown, had no effect on the antinociceptive effects of capsaicin and KR-25018. Considering this result, the antinociceptive effect of capsaicinoid may not be related to the Ruthenium Red sensitive calcium channel which is activated by capsaicin.