Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

The Effects of Korean Wild Vegetables on Blood Glucose Levels and Liver-muscle Metabolism of Streptozotocin-induced Diabetic Rate

한국산 야생식용식물이 당뇨유발 흰쥐의 혈당 및 간과 근육내 에너지원 조성에 미치는 영향

  • 임숙자 (덕성여자대학교 자연과학대학 식품영양학과)
  • Published : 1995.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Attempts were made to determine the effects of 5-Korean wild vegetabel consumptions on blood glucose leveles and orgen-energy metabolisms in streptozotocin-induced diabetic rats. The 5-Korean wild vegetables were : Cassia tora L.(C.t), Lycium chinese Mill(L.c), Trichosanthes kirilowii Max(T.k), Polygonatum odoratum var. Pluriflorum Ohwi(P.o) and Arctium lappa L(A.l). Sixty male Spargue-Dawley rats(160-220g) were induced diabetes mellitus by streptozotocin injection into the tail vein and were devided into 6 groups : a diabetic control and 5-experimental groups. All groups of the rats were fed on a AIN-76 diet, and the 5-experimental groups were fed with each wild vegetable (10%) for four weeks. An increased tendency in body weight of all the groups was observed and the tendency was more significant in L.c, T.k. and P.o. groups. The organ weight of liver and kidney were higher in L.c. and A.l. groups and lower in T.k. group which has shown the improvement from diabetes. Plasma glucose levels were markedly decreased from the 1st week in C.t, T.k. and P.o. groups and the tendency has lasted throughout the four weeks experimental period. The consumption of P.o. has decreased plasma cholesterol level while any significant difference was not seen in plasma protein levels from all the experimental groups. The level of plasma triglyceride was decreased in P.o. group and the levels of plasma free fatty acids were also significantly lower in P.o. and T.k. groups. The liver protein levels were significantly higher in P.o. and T.k. groups and these two groups also showed the negative or relatively small amount of urinary glucose excretion. The experimental group of T.k. has revealed the decreased level of muscles protein and the increased level of muscle glycogen. The 5-Korean wild vegetables contained dietary fiber and 9-analyzed minerals comparable to the ordinary use vegetables.

Keywords

References

  1. Planta Medica v.51 Isolation and hypoglyemic activity of Ephedrans A, B, C, D and E, glycan of Ephedra distachya herbs Konno,C.;Mitzuno,T.;Hikino,H.
  2. Planta Medica v.52 Tormentic acid, a new hypoglycemic agent from poterium ancistroides Villar,A.;Paya,M.;Hortiguela,M.D.;Cortes,D.
  3. Planta Medica v.54 Isolation and hypoglycemic activity of Oryzabrans A, B, C and D, glycan of Oryza sativa bran Hikino,H.;Takahashi,M.;Oshima,Y.;Konno,C.
  4. J Korean Soc Food Nutr v.17 Effcts of Aralia elata extract on experimentally alloxan induced diabetes in rabbits Lee,M.Y.;Lee,J.S.;Sheo,H.J.
  5. J Korean Soc Food Nutr v.16 The effect of Schizandrae fructus extract on blood constituents of alloxan induced diabetic rabbits Sheo,H.J.;Lee,M.Y.;Hwang,G.S.
  6. Korean J Nutr v.25 Hypoglycemic effects of Korean wild vegetables Lim,S.J.;Kim,M.W.
  7. J Nutr v.107 Report of the American Institute of Nutrition : Ad Hoc Committee on standards for nutritional studies. American Institute of Nutrition
  8. Diabetes v.21 no.3 Streptozotocin-induced diabetes and islet cell alterations in rabbits Lazarus,S.S.;Shapiro,S.H.
  9. J Clin Invest v.48 Diabetogenic action of streptozotocin : relationship of dose to metabolic response Alain,J.;Andre,E.;Werner,S.;Albert,E.R.
  10. Scand J Clin & Lab Invest v.12 On the enzymatic determination of blood glucose Raabo,E.;Terkildsen,T.C.
  11. J Clin Chem v.21 Serum triglyceride determinated colorimetry with an enzyme that procedures hydrogen peroxide Giegel,J.L.;Ham,A.B.;Clema,W.
  12. Clin Chim Acta v.466 An easy colorimetric micromethod for routine determination of free fatty acid in plasma Falholt,K.;Lund,B.;Falholt,W.
  13. J Biol Chem v.177 Determination of serum protein by means of the biuret reaction Gornall,A.G.;Bardawill,C.S.;David,M.M.
  14. Methods in Enzymology 3 Chemical procedure for analysis of polysaccharides Hassid,W.Z.;Ahraham,X.
  15. 식품분석 정동효;장현기
  16. Official method of analysis(15th ed) AOAC
  17. Anal Chem v.48 High pressure liquid chromatographic determination of ascorbic acid in selected foods and multivitamin products Sood,S.P.;Sartori,L.E.;Whittmer,D.P.;Haney,W.G.
  18. Statistical Analysis System
  19. Diabetes v.38 Skeletal muscle proteolysis in rat with acute streptozotocin-induced diabetes Smith,O.L.K.;Wong,C.Y.;Gelfand,R.A.
  20. J Nutr v.119 Differential regulation of degradation of myofibrillar and total protein in dietary protein and starvation Kadowak,M.;Harada,N.;Takahashi,S.;Noguchi,T.;Naito,H.
  21. 덕성여자대학교 석사학위 논문 닭의 장풀의 혈당강하효과와 흰쥐의 간조직내 glucose-6-phosphate dehydrogenase의 특성 연구 박수영
  22. J Korean Soc Food Nutr v.21 Pretreatment with nicotinamide to prevent the pancreatic enzymes changes by streptozotocin in rats Shon,K.H.;Kim,S.H.;Choi,J.W.
  23. Diabetes v.24 Physiologic mechanism in the development of starvation ketosis in man Grey,N.J.;Karls,I.;Kipnis,D.M.
  24. New Engl J Med v.309 The metabolic derangements and treatment of diabetic ketoacidosis. Foster,D.W.;MaGarry,J.D.
  25. Diabetes v.40 Regulation of glucose metabolism in livers and kidneys of NOD mice Scoher,M.;Kunjara,S.;Baquer,N.Z.;Mclean,P.
  26. Diabetes v.34 Renal hypertrophy in experimental diabetes changes in pentose phosphate pathway activity Steer,K.A.;Sochor,M.;Mclean,P.
  27. Diabetologia v.13 Renal hypertrophy in experimental diabetes relation to severity of diabetes Seyer-Hansen K.
  28. Thesis collection SM3 Pharm Sci v.7 Studies on the Physiochemical activities of Commelinaeherba extract on the normal and the streptozotocin induced hyperglycemic rats Kim,T.H.;yANG ks;Whang,S.H.
  29. Bull KH Pharma Sci v.5 Studies on the pharmacologic action of the seed of Trichosanthes Kirilowii Maximowiciz and its component Jung,J.C.
  30. Kor J Pharmacog v.11 Pharmacognostical studies on the Rhizome of Polygonatum robustum Nakai. Kim,J.K.;Lee,Y.J.
  31. Bull SK Pharma Sci v.31 Pharmacognostical studies on Polygonatum sibiricum redoute Lee,J.Y.;Won,D.H.
  32. Diabetes v.37 Phvsiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes Bruce,D.G.;Chishoim,D.J.;Storlien,L.H.;Kraegen,E.W.
  33. Diabetes Care v.12 Glycemic effects of traditional European plant treatments for diabetes studies in normal and streptozotocin diabetes mice. ; Traditional Plant medicines as treatments for diabetes. Flatt,S.K.;Day,C.;Flatt,P.R.;Gould,B.J.;Bailey,C.J.;Bailey,C.J.;Day,C.
  34. Diabetes v.31 Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus Abrams,J.J.;Ginsberg,H.;Grundy,S.M.
  35. Diabetes v.39 Cholesterol metabolism in alloxan-induced diabetic rabbits O'meara,N.M.G.;Devery,R.A.M.;Owens,D.;Collins,P.B.;Johnson,A.H.;Tomkin,G.H.
  36. Korean J Nutr v.22 Effect of exogenous insulin on the mwtabolism of normal rat Ju,J.S.;Kim,J.D.;Cheo,M.;Park,Y.E.
  37. Metabolism v.22 Plasma triglyceride transport kinetics in diabetes mellitus Nikkila,E.A.;Kekki,M.
  38. Korean J Nutr v.24 Realtionship of total body fat content and it's distribution to carbohydrate tolerance and serum lipids in diabetics Kim,E.K.;Lee,k.y.;Kim,Y.L.;Huh,K.B.
  39. Bio chem J v.249 Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissue of Rat in vivo Pain,V.M.;Garlick,P.J.
  40. Nutr J v.6 Acute alloxan diabetes alters the activity but not the total quality of acetyl Co A carboxylase in rat liver Roman-Ropez,C.R.;Allred,J.B.
  41. Diabetes v.35 Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic β-cell Meglasson,M.D.;Burch,P.T.;Berner,D.K.;Najafi,H.;Matschinsky,F.M.
  42. INRA Publ. 16 v.Ⅱ Symp. Protein metabolism and nutrition Menke,K.H.;Pion,R.M.
  43. Diabetetes v.39 Insulinomimetic properties of trace elements and characterization of their in vivo mode of action Rosseti,L.;Giaccari,A.;Klein-Robbenhaar,E.;Vogel,L.R.
  44. J Korean Soc Food Nutr v.20 Quantitative analysis and physical properties of dietary fiber in vegetables Park,W.K.;Kim,S.H.
  45. 식품분석표(4차 개정판) 농촌진흥청