Effect of Methionine on Heart Lipid Peroxidation in Rat with Alcohol Administration

Ethanol 급여 흰쥐의 심장 지질과산화에 미치는 Methionine의 영향

  • 조수열 (영남대학교 식품영양학과) ;
  • 박은미 (영남대학교 식품영양학과) ;
  • 김명주 (신일전문대학 식품영양과) ;
  • 이미경 (영남대학교 식품영양학과) ;
  • 성인숙 (영남대학교 식품영양학과)
  • Published : 1995.08.01

Abstract

This study was designed to investigate the effects of methionine(Met) on the activities of heart lipid peroxidation related enzymes in ethanol administrated rats. Male Sprague-Dawley rats were fed on diets containing one of the three levels of Met(0%, 0.3%, 0.9% of kg diet) and ethanol(2.5g/kg of body weight) was administrated as 25v/v% ethanol to ethanol treated groups orally. The rats were sacrificed after 5 and 10 weeks of feeding. Xanthine oxidase(XO) and catalase activities increased with ethanol administration and those activities were higher n Met excessive and deficiency group than those of Met normal group at 5 and 10 weeks dieting. Superoxide dismutase(SOD) activity in heart decreased significantly in Met deficiency and Met excessive group as compared to that of control. Glutathione peroxidase(GSH-Px) activity in heart significantly decreased in Met deficiency group as compared to that of Met excessive and normal group. Glutathione S-transferase(GST) activity of heart tissue significantly increased by ethanol administration. Glutathione(GSH) content in heart decreased with ethanol administration and shwoed no significant differences with Met levels. Ethanol administration increased the content of lipid peroxide(LPO).

Keywords

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