Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Isolation and Identification of a Soil Actinomycetes YBE-316 Producing an Antitumor Antibiotic

항암성 항생물질을 생산하는 토양 방선균 YBE-316의 분리 및 동정

  • 신진이 (연세대학교 식품.생물공학과 생물산업소재연구센터) ;
  • 박재홍 (연세대학교 식품.생물공학과 생물산업소재연구센터) ;
  • 배동훈 (단국대학교 식품공학과) ;
  • 유주현 (연세대학교 식품.생물공학과 생물산업소재연구센터)
  • Published : 1995.06.01
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Abstract

Antitumor antibiotic material was produced by Streptomyces sp. YBE-316 which was isolated from soil, and the optimal culture conditions for the antitumor antibiotic material production were as follows; 2.0% (w/v) sucrose, 0.8% (w/v) polypeptone, 0.4% (w/v) yeast extract, 0.2% (w/v) K$_{2}$HPO$_{4}$, pH 7.0, at 30$\circ$C, 150 rpm and for 100 hours culture. The antitumor antibiotic material had strong antitumor antibiotic activities against most testing tumor cell lines, gram positive and negative bacteria, yeasts, and, especially, Penicillium chrysogenum in fungi.

Keywords

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