Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Independent regulation of antigen processing and presentation on induction of antibody responses to various bacterial antigens in C3H/He mice

  • Kim, Hyung-Su (Department of Microbiology, Research Center for Molecular Microbiology, Seoul National University) ;
  • Jeong, Gajin (Department of Microbiology, Research Center for Molecular Microbiology, Seoul National University)
  • Published : 1995.12.01
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Abstract

Induction of antibody production in C3H/He mice by bacterial infection is regulated through the processing exerted by antigen presenting cells. From the studies with Psudomonas aeruginosa, Salmonella typhimurium, and Micrococcus luteu, lipopolysaccharides (LPS) in Gram negative bacteria, which are known to be T-cell independent B cell mitogen, seem to be the major factor stimulating immune responses via activation of macrophages. Activation of macrophage, however, does not seem to correlate with antibody production. M. luteus was easily eliminatd by activated macrophages, while the processed antigens were immediately releasedd into culture medium before presentation. Nevertheless, antigens from Gram positive bacteria, Staphylococcus aureus and Bacillus subtilis, were very very active in chemotaxis and activation of periotoneal macrophages as well as in antien presnetation, while the very nature of the antigens is not yet clearly understood.

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