Toxicological Research

  • 제11권2호
  • /
  • Pages.289-294
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  • 1995
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

흰쥐에 toluene 투여가 백혈구 xanthine oxidase 및 superoxide dismutase 활성에 미치는 영향

Effect of Toluene Treatment on the Xanthine Oxidase and Superoxide Dismutase Activities in Leukocyte of Bacterial Infected Rats

  • 윤종국 (계명대학교 공중보건학과) ;
  • 이혜자 (계명대학교 공중보건학과) ;
  • 최미애 (계명대학교 공중보건학과)
  • 발행 : 1995.12.01
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초록

This study was designed to observe the effect of tohiene pretreatment on leukocyte variation in whole blood and the oxygen free radical generating, scavenging enzyme activities in neutrophil of bacteria infected rats. Toluene was administered 7 times intraperitoneally at levels of 9.45 mM/kg body weight to the rats and then infected with S. aureus $2\times10^7$ cfu/ml. The toluene treated-rats showed the significantly decreased numbers of lymphocyte and monocytes, but the similiar numbers of neutrophils with the control. Furthermore the increased neutrophils in blood of bacteria infected rats were reduced by the toluene pretreatment. Concomitantly the increased activities of xanthine oxidase and superoxide dismutase in neutrophil of bacteria infected rats were also decreased by the toluene pretreatment. On the other hand, injection of benzaldehyde to rats also led to similiar results in the count of leukocytes, xanthine oxidase and superoxide dismutase activities of neutrophil with those of toluene treated rats. These data suggest that toluene and its intermediate metabolite, benzaldehyde influence on the phagocytosis and defence mechanism of neutrophil.

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참고문헌

  1. Brit. J. Ind. Med. v.28 Haematological Effect of Chronic Benzene Poisoning in 217 Workers Aksoy,M.;Dincol,K.;Akgun,T.
  2. J. Clin Invest v.52 Biological Defense Mechanism. The Production by leukocytes of Superoxide, a Potential Bactericidal Agent Bernard,M.B.;Ruby,S.K.;John,T.C.
  3. Int Arch Occup Environ Health v.60 Epidemiological study on the hepatotoxicity of occupational toluene exposure Boewer,C.;Enderlein,G.;Wollgast,U.;Nawka,S.;Palowski,F.H.
  4. Ann Neurol v.2 persistent cerebellar atoxia after exposure to toluene Boor,J.W.;Hurtig,H.I.
  5. Toxicol Appl Pharmacol. v.61 Evaluation of toluene and acetone inhalant abuse. II Model development and toxicology Brucker,J.V.;Peterson,R.G.
  6. J. Am Coll Toxicol. v.6 Final report on the safety assessment of toluene CIR
  7. Mutation Res. v.47 Genetic toxicology of benzene, toluene, xylene and phenols Dean,B.J.
  8. Toluene in Medical Toxicology Ellenhorn,M.J.;Barceloux,D.G.
  9. Biochem. Pharmacol. v.1 Xanthine Oxidase Increase in Polymorphonuclear Leukocytes and Macrophages in Mice in three Pathological Situations Ezio,T.;Bruno,L.;Claudio,S.;Giovanni,C.
  10. Sci Total Environ. v.42 An overview of environmental and toxicological aspects of aromatic hydrocarbons II. Toluene Fishbein,L.
  11. Chem. Res. v.5 Superoxide radical and Superoxide dismutase Accouts Fridcevich,I.
  12. Am Ind hyg Assoc. v.43 A Hematology survey of workers at a styrene-butakiene synthetic rubber manufacturing plant Harvey,C.;Ted,M.W.
  13. Clin Toxicol v.11 Toxicology of toluene (methy1 benzene) review of current literature Hayden,J.W.;Peterson,R.G.;Brucker,J.V.
  14. Environ Res. v.49 Immunotoxicological evaluation of toluene exposure via drinking water in mice Hsieh,G.C.;Sharma,R.P.;Parker,R.D.R.
  15. Brit. J. Ind. Med. v.45 Neurobehavioural effects and pharmacokinetics of toluene in rats and their relevance to man Kishi,R. et al
  16. N Engl. J. Med. v.275 Permanent encephalopathy from touene inhalation Knox,J.W.;Nelson,J.R.
  17. Biochem Pharmacol v.38 Effect of tolune on rat synaptosomal phospholipid methylation and membrane fluidity Lebel,C.P.;Schstz,R.A.
  18. J. Occup Med. v.31 no.12 Toluene and hepatotoxicity Morris,R.J.
  19. Zentrabl-Bakteriol-Mikrobial-Hyg-B v.178 no.4 Hematological indices of peripheral blood in workers occupationally exposed to benzene, toluene, and xylene Moszczynski,P.
  20. Am. Ind. Hyg. Assoc. J. v.22 Industrial Exposure from Petroleum Naphtha: L Rubber Coating Industry Pagnotto,L.D.;Elkins,H.B.;Brugsch,H.C.;Waldley,J.E.
  21. Toxicol Appl Pharmacol v.82 no.2 A comparative study of the effects of benzene, toluene and xylenes on their in vitro metabolism and drug-metabolizing enzymes in rat liver Pathiratne,A.;Puyear,R.L.;Brammer,J.D.
  22. Int-Arch-Occup-Environ-Health. v.51 no.2 The Haematological and biochemical Pattern in occupational organic solvent poisoning and exposure Pederson,L.M.;Rasmusen,J.M.
  23. Toxicology. v.31 Effects of toluene inhalation on brain biogenic amines in the rat Rea,T.M.;Nash,J.F.;Zabik,J.E.;Born,G.S.;Kessler,W.V.
  24. Toxicol Appl. Pharmacol. v.88 Discriminative stimulus properties of toluene in the mouse Rees,D.C.;Knisely,J.S.;Jordan,S.;Balster,R.
  25. J. Clin. Invest. v.55 The Role of Superoxide Anion Generation in Phagocytic Bactericidal Activity. Studies with Normal and Chronic Granulomatous Disease leukocytes Richard,B.J.;Bernard,B.K.;Hara,P.M.;Joyce,E.L.;Lawrende,S.W.;Robert,L.B.
  26. N Engl. J. Med. v.268 Toluene habituation Satran,R.;Dodson,V.
  27. J. Ind. Hyg. v.10 Chronic Benzol Poisoning Among Women Industrial Workers: A study of Women Exposed to Benzol Fumes in Six Factories Smith,A.R.
  28. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase Stirpe,F.;Della Corte,E.
  29. Science. v.170 Glue sniffing causes heart block in mice Taylor,G.J.;Harris,W.S.
  30. A review Scand J. Work Environ Health v.6 Biotransformation of organic solvents Toftgard,R.;Gustafsson,J.A.
  31. Arch Int Pharmacodyn v.279 Electrocardiograpic effects of toluene in the anesthetized rat Vidrio,H.;Magos,G.A.;Lorenzana,J.M.
  32. Enzymatic Basis of Detoxication v.1 Aldehyde oxidizing enzymes Weiner,H.;ed.Jakoby,W.B.
  33. Clinical Hematology. ed6 Wintrobe,M.M.
  34. Ann. Intern Med. v.103 Toluene sniffing and severe sinus bradycardia Zee Cheng,C.S.;Mueller,C.E.;Gibbs,H.R.