YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Preparation of Antiinflammatory Herbal Drug, SKI306X.

항염작용을 갖는 신규 생약복합제 SK1306X의 분리 및 항염작용

  • 박광식 (선경인더스트리 생명과학연구소) ;
  • 김환수 (선경인더스트리 생명과학연구소) ;
  • 안재석 (선경인더스트리 생명과학연구소) ;
  • 김택수 (선경인더스트리 생명과학연구소) ;
  • 박병욱 (선경인더스트리 생명과학연구소) ;
  • 곽의종 (선경인더스트리 생명과학연구소) ;
  • 한창균 (선경인더스트리 생명과학연구소) ;
  • 조용백 (선경인더스트리 생명과학연구소) ;
  • 김기협 (선경인더스트리 생명과학연구소)
  • Published : 1995.08.01
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Abstract

Antiinflammatory activities of the solvent fractionates of several herbal medicines were investigated and SKI306X was prepared from the active principles of three herbal medicines, Prunella vulgaris, Trichosantlies kirilowii and Clematis mandshurica. SK1306X was shown to have strong inhibitory effects on acetic acid-induced pain, carrageenan-induced paw edema and adjuvant induced arthritis. LD50 of SKI306X was more than 5 g/kg in rat, so generally nontoxic. Chemical analysis revealed that oleanolic acid and rutin, which are known to have various antiinflammatory activities, were contained in it. These results suggest SK1306-X may become a useful drug for the treatment of inflammatory diseases such as rheumatoid arthritis.

Keywords

References

  1. 원본국역동의보감 동의보감편찬위원회
  2. 한약임상응용 이상인;안덕균;신민교;노승현;이영종;김선희
  3. 중약대사전 相賀徹未
  4. Harrison's principles of internal medicine(twelfth edition) v.2 Rheumatoid Arthritis Lipsky,P.E.;Wilson,J.E.(et al.)(ed.)
  5. Arthritis Rheum v.29 Survival. Prognosis and cause of death in rheumatoid arthritis Mitchel,D.M.(et al.)
  6. Fed. Proc. v.18 Acetic acid for analgesic screening Koster,R.;Anderson,M.;de Beer.E.J.
  7. Pro. Soc. Exp. Biol. Med. v.111 Carrageenan induced edema in hind paw of the rat as an assay for antiinflammatory Winter,C.A.;Risley,E.A.;Nuss,G.W.
  8. Br. J. Pharmacol. Chemothera. v.21 Chemotherapy of arthritis induced in rats by mycobacterial adjuvant Newbould,B.B.
  9. J. Gen. Physiol. v.66 Human platelet secretion and aggregation induced by calcium ionophores Feinstein,M.B.;Fraser,C.
  10. J. Biol. Chem. v.240 Lysosomal hyaluronidase Nathan,N.;Arson,Jr.;Davidson,E.A
  11. Proc. Natl. Acad. Sci. v.71 no.9 Prostaglandin Endoperoxides. Novel transformations of arachidonic acid in human platelets Hamberg,M.;Samuelsson,B.
  12. Biochem. Pharmacol. v.33 Inhibition in vitro platelet aggreation and arachidonic acid metabolism by flavone Mower,R.L.;Landolfi,R.;Steiner,M.
  13. Science v.228 Angiogenesis induced by degradation product of hyaluronic acid West,D.C.;Hampson,I.N.
  14. Physiol. Rev. v.58 Physiological function of connective tissue polysaccharides Comper,W.D.;Laurent,T.C.
  15. Arch. Int. Pharmacodyn. Ther. v.111 A method for measurement of analgesic activity of inflamed tissue Randall,L.O.;Selitto,J.J.
  16. J. Pharmacol. Exp. Therap. v.80 The evaluation of the analgesic action of pethidine hydrochloride (Dimerrol) Woolfe,G.;MacDonald,A.D.
  17. Am. J. Chin. Med. v.17 no.3-4 The hypotensive action of Desmodium Styracifolium and Clematis chineisis Ho,C.S.;Wong,Y.H.;Chiu,K.W.
  18. Mutagenesis v.9 Moderate inhibition of mutagenicity of benz [a]pyrene, 1.6-dinitropyrene and 3.9-dinitrofluoranthene by chinese medicianl herbs Horikawa,K.;Mohri,T.;Tanaka,Y.;Tokiwa,H.
  19. Life Sci v.55 Minireview: trichosanthin-a protein with multiple pharmacological properities Shaw,P.C.;Chan,W.L.;Yeung,H.W.
  20. J. Pharm. Pharmacol. v.44 Anti-inflammatory activity of oleanolic acid in rats and mice Singh,C.B.;Singh,S.;Gupta,B.D.;Banerjee,S.K.
  21. Biochemical. Int. v.24 Protective effect of oleanolic acid and ursolic acid against lipid peroxidation Balanehru,S.;Nagarajan,B.
  22. Biochemic. J. v.277 no.Pt2 Inhibition of human leucocyte elastase by ursolic acid. Evidence a binding site for pentacyclic triterpenes Ying,Q.L.;Rinehart,A.R.;Simon,S.R.;Cheronis,J.C.
  23. Chung-Kuo-Tao-Li-Hsueh-Pao. v.10 Effects of oleanolic acid on immune system and type I allergic reaction Dai,Y.;Hang,B.Q.;Li,P.Z.;Tan,L.W.
  24. Free Radic. Biol. Med. v.16 The correlation between active oxygens scavenging and antioxidative effects of flavonoids Hanasaki,Y.;Ogawa,S.;Fukui,S.
  25. The Flavonoids The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer Elliott,M.Jr.;Chithan,K.;Harbon,J.B.(ed.)