YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Mechanism of Naproxen-Induced Antidiuretic Response in Dog

나프록센의 항이뇨작용 기전

  • Published : 1995.06.01
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Abstract

This study was attempted to investigate the mechanism of retention of sodium and water by naproxen which is a drug among nonsteroidal anti-inflammatory drugs in dogs. Napoxen, when given intravenously in doses ranging from 30 mg to 100 mg/kg, elicited antidiuresis accompanied vath the decrease of osmolar clearance(Cosm) and amounts of sodium excreted in urine(E$_{Na}$), with the increase of sodium reabsorption rate in renal tubule(R$_{Na}$) and ratio of potassium against sodium (K/Na). Naproxen infused into a renal artery in doses ranging from 1.0mg to 3.0mg/kg/min produced both diuretic action in infused kidney and antidiuretic action in control kidney. Naproxen injected into carotid artery in doses ranging from 10.0 mg to 30.0 mg/kg exhibited antidiuretic action. Changes of renal function in the circumstances of above two antidiuresis were the same with aspect of intravenous naproxen. Antidiuretic action of naproxen injected into carotid artery was not affected by renal denervation, was blocked by pretreatment with i.v. arachidonic acid, prostaglandin precursor, or i.v. indomethacin, cyclooxygenase inhibitor. Naproxen injected into carotid artery abolished the diuretic action of i.v. spironolactone, aldosterone antagonist, and i.v. spironolactone blocked the antidiuretic action of naproxen given into carotid artery. The results suggest that naproxen produced antidiuresis, and sodium and water retention through the central system, the mechanism being related to the prostaglandin biosynthetic inhibition and aldostercfne like action.

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References

  1. Basic and Clinical pharmacology (3th ed.) Katzung,B.C.
  2. The Pharmacological Basis of Therapeutics (8th ed.) Gilman,A.G.;Rall,T.W.;Nies,A.S.;Tayler,P.
  3. The Pharmacological Basis of Therapeutics (8th ed.) Gilman,A.G.;Rall,T.W.;Nies,A.S.;Tayler,P.
  4. FASEB J. v.1 Inflammation and mechanism of action of antiinflammatory drugs Vane,J.R.;Botting,R.
  5. Symposium (Various authors): Anti-Reumatic drugs Huskisson,E.C.(ed.)
  6. Am. J. Physiol. v.234 Nonsteroidal anti-inflammatory drugs cause sodium and water retention in the rat Feldman,D.;Loose,D.S.;Tan,S.Y.
  7. Prostaglandins v.1 Natriuretic hormone and the renal prostaglandins Lee,J.B.
  8. Am. J. Physiol. v.237 Renin release from filtering and nonfiltering kidneys stimulated by PG12 and PGD2 Seymour,A.A.;Davis,J.O.;Freeman,R,H.;DeForrest,J.M.;Rowe,B.P.;Williams,G.M.
  9. Nature v.271 Renal actions of prostacyclin Bolger,P.M.;Eisner,G.M.;Ramwell,P.W.;Slotkoff,L.M.;Corey,R.J.
  10. Circ. Res. v.36 Enhanced renal prostaglandin production in the dogⅠ. Effects of renal function Tannenbaum,J.;Splawinsky,J.A.;Oates,J.A.;Nies,A.S.
  11. Am. J. Physiol. v.220 Effect of prostaglandin E₁on renin in the dog Werning,C.;Vetter,W.;Weidman,P.;Schweikett,H.U.;Stiel,D.;Seigenthaler,W.
  12. Role of renal prostaglandins during antidiuresis and waterdiuresis in man v.21 Walker,R.M.;Brown,R.S.;Stoff,J.S.
  13. Am. J. Physiol. v.241 Indomethacin impairs water diuresis in the DI rat: Role of prostaglandins independent of ADH Stoff,J.S.;Rosa,R.M.;Silva,P.;Epstein,F.H.
  14. Nature Lond. v.205 Effect of prostaglandin(PGE₁) on the permeability response of the toad bladder to vasopressin, theophylline and adenosine 3',5'-monophosphate Orloff,J.;Handler,J.S.;Bergstrom,S.
  15. J. Clin. Invest. v.56 Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney Anderson,R.J.;Berl,T.;McDonald,K.M.;Schrier,R.W.
  16. J. Clin. Invest. v.56 Effect of acute unilateral renal denervation in the rat Elsa,B.R.;Romulo,E.C.;Enrique,P.M.;Robert,A.M.;Carl,W.G.
  17. Quantative clinical chemistry by Peters and Van Slyke v.2 Phillis,B.A.
  18. J. Clin. Invest. v.21 The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man Smith,H.W.;Finkelstein,N.;Aliminosa,L.;Crawford,B.;Graber,B.
  19. Statistical Methods (6th ed.) Snedecor,G.W.;Cochran,W.G.
  20. Am. J. Physiol.(Renal Fluid Electrolyte Physiol) v.240 Integrated actions of renal medullary prostaglandins in the control of water excretion Stokes,K.B.
  21. Adv. Exp. Biol. v.259 The biosynthesis and action of prostaglandins in the renal collecting tubule and thick ascending limb Smith,W.L.;Sonnenberg,W.K.;Allen,M.L.;Watanabe,T.;Zhu,J.;EI-Harich,E.A.
  22. J. Pharmacol. Exp. Ther. v.206 The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of furosemide in the dog Deta,J.L.;Rane,J.;Gerkens,G.R.;Wilkinson,A.S.;Branch,R.A.
  23. J. Pharmacol. Exp. Ther. v.210 Analysis of the effect of indomethacin on the response to furosemide in man: Effect of dose of furosemide Brater,D.C.
  24. Yakhak Hoeji v.29 Studies of diuretic action of bumetanide Ko,S.T.;Kim,I.Y.
  25. Am. J. Physiol. (Renal Fluid Electrolyte Physiol) v.232 Renal response to vasopressin after inhibition of prostaglandin synthesis Fejes-Toth,G.;Magyar,A.;Walteer,J.
  26. J. Biol. Chem. v.263 Regulation of cyclic AMP metabolism in rabbit cortical collecting tubule cells by prostaglandins Sonnenburg,W.K.;Smith,W.L.
  27. Am. J. Physiol. (Cell Physiol) v.257 no.26 Endothelin, a peptide inhibitor of Na -$K^+$-ATPase in intact renal tubular epithelial cells Zeidel,M.L.;Brady,H.R.;Kone,B.C.;Gullans,S.R.;Brenner,B.M.
  28. Am. J. Physiol. (Renal Fluid Electrolyte Physiol) v.257 Prostaglandin E2 inhibits Na -$K^+$-ATPase activity in the inner medullary collecting duct Jabs,K.;Zeidal,M.L.;Silva,P.
  29. Am. J. Physiol. (Renal Fluid Electrolyte Physiol) v.264 PGE2 inhibits Na-K-ATPase activity and ouabain binding in MDCK cells Cohen-Luria,R.;Rimon,G.;Moran,A.
  30. The pharmacological basis of therapeutics (7th ed.) Gilman,A.L.;Goodman,L.S.;Rall,T.W.;Murad,F.
  31. Yakhak Hoeji v.34 Effect of arachidonic acid on renal function of dog Ko,S.T.;Park,H.S.
  32. J. Pharmacol. Expt. Ther. v.198 The effect of indomethacin on renal function in pentobarbital-anesthetized dogs Feigen,L.P.;Klainer,E.;Chapnick,B.M.;Kadowitz,P.J.
  33. The Physiological Basis of Diuretic Therapy Pitts,R.F.
  34. Am. J. Physiol. v.211 Micropuncture study of distal tubular potassium and sodium transport in rat nephron Malnic,G.;Klose,R.M.;Giebisch,G.
  35. Am. J. Physiol. v.211 Microperfusion study of distal tubular potassium and sodium transfer in rat kidney Malnic,G.;Klose,R.M.;Giebisch,G.
  36. Am. J. Med. v.36 Renal tubular transfer of sodium, chloride and potas sium Giebisch,G.;Windbager,E.E.
  37. Jap. J. Nephrol. v.7 Potassium excretion by the kidney Berliner,R.W.
  38. J. Clin. Ivest. v.44 The site of action of furosemide and other sulfonamide diuretics in the dog Suki,W.;Rector,F.C.Jr.;Seldin,D.W.
  39. Am. J. Physiol. v.26 The effect of chlorothiazide on renal excretion of electrolytes and free water Heinemann,H.O.;Demartin,F.F.;Laragh,J.H.
  40. The pharmacological basis of Therapeutics (7th ed.) Gilman,A.G.;Goodman,L.S.;Rall,T.W.;Murad,F.
  41. Kidney Int. v.20 Mechanism of the antimineral cortcoid effects of spironolatone Corvol,P.;Claire,M.;Oblin,M.E.;Greering,K.;Rossier,B.
  42. The Pharmacological Basis of Therapeutics (7th ed.) Gilman,A.G.;Goodman,L.S.;Rall,T.W.;Murad,F.
  43. Int. Rev. Physiol. v.24 Reflex control and modulation of ACTH and corticosteroids Gann,D.S.;Dallman,M.F.;Engeland,W.C.
  44. Science v.213 Characterization of a 41-residue ovine hypoth alamic peptide that stimulates secretion of corticotropin and β-endorphin Vale,W.;Spies,J.;Rivier,C.;Rivier,J.