YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Selection of Clinically Isolated Strains for Evaluation of the Newly Synthesized Antibiotics

새로운 $\beta$-lactam계 항생물질 개발을 위한 검정용 균주의 개발

  • Published : 1995.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Clinically isolated bacterial strains resistant to almost of all the clinically superior .betha.-lactam antibiotics can be used to screen the promising ones among the newly synthesized $\beta$-lactam antibiotics. To select the resistant strains, the susceptibility of 389 strains of S. aureus, 144 strains of coagulase negative staphylococci, 509 strains of E. coli, 115 strains of E. cloacae and 187 strains of P. aeruginosa to methicillin, ampicillin, piperacillin and gentamicin was determined. The susceptibility of 19 bacterial strains selected through the first screening to cefixime, cefotiam, cefotaxime, flomoxef, cepfirome, cefdnir, SCE-2787, panipenem and imipenem was determined. Four strains of S. aureus finally selected have high degree of resistance to almost of all $\beta$-lactam antibiotics used and also produce $\beta$-lactamases. These 4 strains of S. aurues can be used to screen effectively the promising $\beta$-lactam antibiotics among the numerous numbers of the newly synthesized $\beta$-lactam antibiotics.

Keywords

References

  1. Science v.257 The crisis in antibiotic resistance Harold,C.N.
  2. Ann. Rev. Microbiol. v.41 Chromosomal cephalosporinases responsible for multiple resistance to newer β-lactam antibiotics Sanders,C.C.
  3. Antimicrob. Agents. Chemother. v.27 Role of β-alctam hydrolysis in the mechanism of resistance of a β-lactamase-constitutive Ent. cloacae to expanded-spectrum β-lactams Nikaido,H.;Vu,H.
  4. Antimicrob. Agents. Chemother. v.37 Molecular basis of β-lactamase induction in bacteria Bennet,P.M.;Chopra,I.
  5. Antimicrob. Agents. Chemother. v.33 Characterization of β-lactamase Bush,K.
  6. Antimicrob. Agents. Chemother. v.30 Methodology for the study of β-lactamase Bush,K.;Sykes,R.B.
  7. NCCLS document MI-3A v.13 Methods for dilution antimicrobial susectibility tests for bacteria NCCLS(National Commitee for Clinical Laboratory Standards)
  8. Manual of methods for genernal bacteriology Simbert,R.M.;Krieg,N.R.
  9. Antimicrob. Agents. Chemother. v.22 Purification and properties of inducible penicillin β-lactamase isolated from Ps. maltophilia Saino,Y.;Kobayashi,F.;Inoue,M.;Mitsuhashi,S.
  10. Antimicrob. Agents. Chemother. v.23 Characterization of β-lactamase induction in Ent. cloacae Gootz,T.D.;Sander,C.C.
  11. Ent. cloacae. J. Gen. Microb. v.130 Nonspecific induction of β-lactamase Cullman,W.;Dalhoff,A.;Dick,W.
  12. Antimicrob. Agents. Chemother. v.33 In vitro activity and β-lactamase stability of a new carbapenem, SM-7338 Neu,H.C.;Novelli,A.;Chin,N.X.
  13. Nature v.208 Interaction of cephaloridine with penicillinase-producing gram-negative bacteria Hamilton-Miller,J.M.T.;Smith,J.T.;Knox,P.R.
  14. Biochem. J. v.139 A spectrophotometric assay of β-lactamase action Waley,S.S.
  15. Enzyme assays Eisenthal,R.;Danson,M.J.
  16. J. Korean. Soc. Chemother. v.11 Antimicrobial susceptibilities of bacteria isolates during1988-1992 Lee,K.W.;Chong,Y.S.;Kwon,O.H.;Park,H.S.;Kim,J.M.
  17. Ann. Rev. Biochem. v.52 Penicillin-binding proteins and the mechanism of action of β-lactam antibiotics Waxman,D.J.;Strominger,J.L.
  18. Science v.99 Extraction of a highly potent penicillin inactivator from penicillin resistant staphylococci Kirby,W.M.
  19. Antimicrob. Agents Chemother. v.17 Isolation of an ampicillin-resistant, non-β-lactamase producing strain of H. influenzae Markowitz,S.M.