YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Ion-Selective Electrodes in Drugs Analysis: Verapamil-Selective Polymeric Membrane Electrodes Based on Calix[4]arene and Dibenzo-18-crown-6-ether Ionophores

이온 선택성 전극을 이용한 의약품 정량: Calix[4]arene과 Dibenzo-18-crown-6-ether에 의한 verapamil-선택성 polymeric membrane electrode

  • 이은엽 (경성대학교 약학대학 약학과) ;
  • 김성진 (㈜현대약품연구소) ;
  • 김영학 (경성대학교 약학대학 약학과) ;
  • 김재현 (국립보건안전연구원) ;
  • 허문회 (경성대학교 약학대학 약학과) ;
  • 안문규 (경성대학교 약학대학 약학과)
  • Published : 1995.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

PVC membrane electrodes based on the lipophilic neutral carrier, dibenzo-18-crown-6, cyclic oligomers of teit-butylphenol-formaidehyde condensates, calix[4]arenes as the active sensors for verapamil have been prepared and tested in a variety of plasticizers. At pH 5.0, the electrode exhibits a Nernstian response in the range of 10$^{-2}$~5$\times$10$^{-5}$ M verapamil with a slope of 49.1$\pm$0.5mV per concentration decade. The electrode constructed in this work can be used continuously for at least 1 month before any damage to the membrane occurs. And the analyses of the local anesthetic amine, which are good to select a specific compound in a mixed solution, were also accomplished by using of another neutral carrier, a DB18C6, for comparing with calix[4]arene.

Keywords

References

  1. Analyst v.116 Determination of ethaverin and papaverine using ionselective electrodes Eppelsheim,C.;Aubeck,R.;Hampp,N.
  2. Anal. Chem. v.65 Potentiometric discrimination of organic amines by a liquid membrane electrode based on a lipophilic hexaester of calix[6]arene Odashima,K.;Yagi,K.;Tohda,K.;Umezawa,Y.
  3. Analyst v.118 Ion-selective electrodes in organic analysis; primary amine selective polymeric membrane electrodes based on a calix[6]arene ionophore Chan,W.H.;Shiu,K.K.;Gu.W.H.
  4. Talanta v.36 Potentiometric ion and bio-selective electrodes based on asymmetric cellulose acetae membrane Meyerhoff,M.E.;Cha,G.S.
  5. Anal. Chem. v.65 Asymmetric carbonate ion-selective cellulose acetate membrane electrodes with reduced salicylate interference Lee,K.S.;Shin,J.H.;Cha,G.S.;Shin,D.S.;Kim,H.D.
  6. J. Korean Chem. Soc. v.38 Host-guest interaction of cyclic and acyclic polyethers with alkylammonium ions Jung,J.H.;Kim,D.Y.;Lee,S.S.
  7. Analyst v.114 Sodium-selective polymeric membrane electrodes based on calix[4]arene ionophores Cadogan,A.M.;Diamond,D.;Smyth M. R.;Desay,M.;McKervey,M.A.;Harris,S.J.
  8. Anal. Chem. v.62 Polymeric membrane sodium-selective electrodes based on lipophilic calix[4]arene derivatives Kimura,K.;Miura,T.;Matsuo,M.;Shono,T.
  9. Anal. Chem. v.65 Study of the behavior of calix[4]arene-based sodium-selective electrodes by means of ANOVA Careri,M.;Casnati,A.;Guarinoni,A.;Mangia,A.;Mori,G.;Pochini,A.;Ungaro,R.
  10. J. Korean Chem. Soc. v.37 Tallium(Ⅰ) ion-selective electrodes based on crown ethers Kim,S.M.;Jung,S.U.;Kim,J.;Lee,S.S.;Kim,J.S.
  11. J. Korean Chem. Soc. v.38 Bis-crown ether based ion-selective membrane electrodes as a monovalent cation detector for ion chromatography Lee,D.K.;Lee,I.C.;Kim,J.Y.;Chang,S.H.;Han,S.H.;Cha,G.S.
  12. Anal. Chem. v.62 Design of a calcium-selective optode membrane based on neutral ionophores Morf,W.E.;Seiler,K.;Rusterholz,B.;Simon,W.
  13. Analyst v.118 Sodium-selective membrane electrode based on p-tert-butylcalix[4]-arene methoxyethylester Cunningham.K.;Svehla,G.;Harris,S.J.;Mckervey,M.A.
  14. Analyst v.116 Amitriptyline-selective plastic membrane sensors and their pharmaceutical application Bunaciu,A.A.;Ionescu,M.S.;Palivan,C.;Cosofret V. V.
  15. Analyst v.116 Indomethacin ion-selective electrode based on a bis(triphenylphophoranylidene) ammonium-indomethacin complex Aubeck,R.;Brauchle,C.;Hampp,N.
  16. Anal. Letts. v.27 New ampicillin selctive plastic membrane and coated metal elecrodes based on ampicillinium phophotungstate ion pair Rizk,M.S.;Issa,Y.M.;Shoukry,A.F.;Abdel-Aal,M.M.
  17. Anal. Chem. v.60 Potentiometric adenosine triphosphate polyanion sensor using a lipophilic macrocyclic polyamine liquid membrane Umezawa,Y.;Kataoka,M.;Takami,W.;Kimura,E.;Koike,T.;Nada,H.
  18. Bull. Korean Chem. Soc. v.11 Selective transport of amino acids derivative through calix[6]arene-based liquid membrane Chang,S.K.;Son,H.J.;Hwang,H.S.;Kang,Y.S.
  19. Anal. Letts. v.16 Ion selective crown-ether electrodes for local anesthetic cations Shirahama,K.;Kamaya,H.;Ueda,I.
  20. Anal. Chem. v.61 Amphetamine selective electrodes based on dibenzo-18-crown-6 and dibenzo-24-crown-8 liquid membrane Hassan,S.S.M.;Elnemma,E.M.
  21. Talanta v.7 Symmetrical, unsymmstrical and brigde calix[4]arene derivatives as neutral carrier ionophores in poly(vinyl chlorides) membrane sodium slective electrodes O'Connor,K.M;Cherry,M;Svehla,G.;Harris,S.J;Mckervey,M.A.
  22. Microchemical J. v.39 a double-membrane ion-selective electrodes for the potentiometric determination of potassium Diaz,C.;Vidal,J.C.;Galbam,J.;Urarte,M.L.;Lanaja,J.