YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex

Dithiocarbamate Chitosan을 Matrix로 이용한 고분자 약물의 개발 : Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex 의 생성 및 항균성

  • Published : 1995.02.01
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Abstract

Coupling of tetracycline(Tc) to dithiocarbamate chitosan(DTCC) via chelate bond was investigated varying reaction time, concentration, temperature, pH, and Ca(II)/Tc ratio. The amount of Tc bound to matrix increased to give a maximum and decreased as the reaction proceeded. The degree and rate of dissociation of Tc complex were affected by the reaction temperature, and pH. By running the reaction at low temperature and pH, the degree of dissociation was greatly diminished. Properties of drug-release from DTCC-Ca(II)-Tc complex were studied by batch- and flow-method and release of Tc and CA(II) by flow method followed nearly zero-order. DTCC-Ca(II)-Tc showed very prolonged antimicrobial activity compared to that of free Tc.

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References

  1. Bioactive Polymeric Systems Gebelein,C.G.(ed.);Carrarher,C.E.(ed.)
  2. Anionic Polymeric Drugs Donamura,L.G.(ed.);Ottenbreite,R.M.(ed.);Vogl,O.(ed.)
  3. Drug Design v.Ⅹ Polymeric Drug Delevery System Kim,S.W.;Peterson,R.V.;Fejica,J.;Ariens,E.L.(ed.)
  4. Text. Res. J. v.53 no.3 Use of Aluminum or Titanium Compounds to Bind Antimicrobial Agent to Cotton Fabrics Morris,C.M.;Welch,C.M.
  5. Text. Res. J. v.53 no.12 Antimicrobial Finishing of Cotton with Zinc Pyrithione Morris,C.M.
  6. Arch. Pharm. Res. v.12 no.2 Development of Cotton Fabrics with Prolonged Antimicrobial Action Kim,Y.M.;Han,S.K.;Lee,K.J.;Kim,Y.T.
  7. Thesis for M. Sc., College of Pharmacy, Pusan National University Synthesis and Properties of Cellulose Xanthate-Matal Chelate of Antimicrobial Agent Jung,Y.J.
  8. Compiled for IUPAC Stability Constants of Metal-Iom Complexes Perrin,D.
  9. Compiled for IUPAC Stability Constants of Metal-Iom Complexes Sillen,L.;Martell,A.
  10. Principle and Application of Metal Chelation Bell,C.
  11. Applied Bioactive Polymeric Materials Development of Polymers with Anti-infectious Properties B.Jansen;G.Peters;S.Schareina;H.Steinhauser;F. Schumacher Perdreau;G.Pluverer;Charles G. Gebelein(ed.);Charles,E.(ed.);Carraher, Jr.(ed.);Van R. Foster(ed.)