약학회지 (YAKHAK HOEJI)

  • 제39권1호
  • /
  • Pages.6-9
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  • 1995
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

다제내성 황색포도상구균이 가지고 있는 테트라사이클린 내성 플라스미드의 동정

Characterization of Tetracycline Resistance Plesmid of Multidrug-resistant Staphylococcus aureus

  • 발행 : 1995.02.01
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초록

The clinical isolate Staphylococcus aureus SA2 had four kinds of plasmids and was resistant to ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin, kanamycin, methicillin, streptomycin, tetracycline and tobramycin. Transformation experiment demonstrated that 4.44 kb plasmid(pKH6) encoded resistance to tetracycline. The cleavage map of pKH6 was determined by restriction enzyme mapping techniques. The cleavage map is given for EcoRV, HindIII, HpaI, HpaII, KpnI and Xbal. Restriction endonucleases BamHl, BglI, BGIII, BstEII, EcoRI, HaellI, PstI, PvuII, SalI, Smal, and Xhol have no site on this plasmid. The restriction map revealed extensive structural homology between pKH6 and pT181.

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참고문헌

  1. Plasmid v.1 Incompatibility and molecular ralationships between small staphylococcal plasmids carrying the same resistance marker Iordanescu,S.;Surdeanu,M.;Della Latta,P.;Novick,R.
  2. Microbiological Rev. v.51 Antimicrobial resistance of Staphylococcus aureus: genetic basis Lyon,B.R.;Skurray,R.
  3. Gene v.21 Construction and propagation of deletion derivatives of staphylococcal tetracycline-resistance plasmid pTP-5 in Bacillus subtilis Noguchi,N.;Shishido,K.;Ando,T.;Kono,M.
  4. Proc. Natl. Acad. Sci. v.79 Coding sequence for the pT181 repC product: a plasmid-coded protein uniquely required for replication Novick,R.P.;Adler,G.K.;Majumder,S.;Khan,S.A.;Carleton,S.;Rosenblumn,W.D.;Iordanescu
  5. J. Bacteriol. v.134 Cleavage maps of a tetracycline plasmid from Staphylococcus aureus Shafferman,A.;Shalita,Z.;Hertman,I.
  6. Plasmid v.10 Complete nucletide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus Khan,S.A.;Novick,R.P.
  7. 약학회지 v.36 황색포도상구균에서 테트라사이클린 내성을 나타내는 플라스미드의 동정 김기현;김종명;문경호
  8. 약학회지 v.34 황색포도상구균의 항생제 내성양상 강재선;문경호
  9. 약학회지 v.36 황색포도상구균의 항생제 다제내성을을 갖는 플라스미드의 동정 김기현;이대운;김종명;문경호
  10. 약학회지 v.37 대제내성 황색포도상구균이 가지고 있는 클로람페니콜 내성 플라스미드의 동정 이대운;문경호
  11. J. Med. Microbiol. v.19 Antibiotic resistance in Staphylococcus aureus isolated at an Australlian hospital between 1946 and 1981 Gillespie,M.T.;May,J.W.;Skurray,R.A.
  12. J. Gen. Microbiol. v.132 Detection of an integrated tetracycling resistance plasmid in the chromosome of methicillin-resistant Staphylococcus aureus Gillespie,M.T.;May,J.W.;Skurray,R.A.