Archives of Pharmacal Research

  • 제18권5호
  • /
  • Pages.356-360
  • /
  • 1995
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis of 1-Aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triaszine-6-thione and their Latentiation Products as Antithyroidal Agent

  • Methrotra, S. (Department of Chemistry, Banaras Hindu University) ;
  • Roychowdhury, P.K. (Department of Chemistry, Banaras Hindu University) ;
  • Pandey, K.K. (Department of Chemistry, Banaras Hindu University) ;
  • Srivastava, P.K. (Department of Chemistry, Banaras Hindu University)
  • 발행 : 1995.10.01
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초록

Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones hvae been synthesized by known methods (Coerdeler et al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-ary-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione which on further reaction with different ${\alpha},{\;}{\beta}-unstaturated$ carbonyl compounds and aryl-cyanamide ydrochloride affordered the related adducts. Some of these compounds show appreciable antithyroidal activity.

키워드

참고문헌

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