한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제5권2호
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- Pages.1-12
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- 1995
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
충수돌기염 환자에서 겐타마이신의 임상약물동태
Clinical Pharmacokinetics of Gentamicin in Appendicitis Patients
- Cho Jun-Shik (College of Pharmacy, Chosun University) ;
- Jung HaeGwang (College of Pharmacy, Chosun University) ;
- Burm Jin Pil (College of Pharmacy Chosun University) ;
- Lee JinHwan (College of Pharmacy, Chosun University) ;
- Kim SungHwan (College of Medicine, Chosun University)
- 발행 : 1995.12.01
초록
The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using linear least square regression(LLSR) and Bayesian analysis in Korean normal volunteers and appendicitis patients. Nonparametric expected maximum(NPEM) algorithm for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were
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