Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 5 Issue 2
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- Pages.1-12
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- 1995
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Clinical Pharmacokinetics of Gentamicin in Appendicitis Patients
충수돌기염 환자에서 겐타마이신의 임상약물동태
- Cho Jun-Shik (College of Pharmacy, Chosun University) ;
- Jung HaeGwang (College of Pharmacy, Chosun University) ;
- Burm Jin Pil (College of Pharmacy Chosun University) ;
- Lee JinHwan (College of Pharmacy, Chosun University) ;
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Kim SungHwan
(College of Medicine, Chosun University)
- Published : 1995.12.01
Abstract
The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using linear least square regression(LLSR) and Bayesian analysis in Korean normal volunteers and appendicitis patients. Nonparametric expected maximum(NPEM) algorithm for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were
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