좌귀음(左歸飮)과 우귀음(右歸飮)이 노화(老化) Rat의 뇌(腦) 과산화(過酸化) 지질(脂質) 생성(生成) 및 활성산소(活性酸素) 생성계(生成系) 효소(酵素) 활성(活性)에 미치는 영향(影響)

Effects of Jwagyuyeum and Woogyuyeum of Free Radical Generating Enzyme Activities and Lipid Peroxidation in Senile Rat's Brain

Jwagyuyeum and Woogyuyeum, being known to reinforce Kidney-yin and -yang, were tested for the effects of on free radical generating enzyme and lipid peroxidation in senile rat brain. In vitro, levels of lipid peroxide in tissues of brain were proportionally decreased to concentration of extracts prepared from Jwagyuyeum and Woogyuyeum. They were much more decreased, when lipid peroxidation was induced with ferrous iron ($Fe^{-2}$). In vivo, after both berbs were administered to the rat. levels of lipid peroxide in brain were decreased. especially it was much more decreased using Jwagyuyeum. Also, enzyme activities of xanthine oxidase and aldehyde oxidase in brain were decreased. The ratio of type conversion of the brain xanthine oxidase was lowered in both, especially Jwagyuyeum was much more done. These results suggest that Jwagyuyeum and Woogyuyeum decrease the activities of free radical generating enzymes such as xanthine oxidase and aldehyde oxidase which form lipid peroxide, Consequently both herbs might delay aging.