Applied Biological Chemistry
- Volume 38 Issue 6
- /
- Pages.516-521
- /
- 1995
- /
- 2468-0834(pISSN)
- /
- 2468-0842(eISSN)
Structure Elucidation of a Potent Anti-MRSA Antibiotic, AM3, Produced by Streptomyces sp.
방선균에 의해 생산된 항 MRSA 항생물질 AM3의 구조 연구
-
Lim, Yoong-Ho
(Dept. of Agricultural Chemistry College of Agriculture Kon-Kuk University)
;
- Chang, Jun-Hwan (R&D Center, Cheil Foods & Chemicals Inc.) ;
- Kim, Jong-Hoon (R&D Center, Cheil Foods & Chemicals Inc.) ;
- Suh, Jung-Woo (R&D Center, Cheil Foods & Chemicals Inc.) ;
- Jung, Jae-Kyung (R&D Center, Cheil Foods & Chemicals Inc.) ;
- Lee, Chul-Hoon (R&D Center, Cheil Foods & Chemicals Inc.)
-
임융호
(건국대학교 농화학과)
;
- 장준환 (제일제당(주) 종합연구소 발효연구팀) ;
- 김종훈 (제일제당(주) 종합연구소 발효연구팀) ;
- 서정우 (제일제당(주) 종합연구소 발효연구팀) ;
- 정재경 (제일제당(주) 종합연구소 발효연구팀) ;
- 이철훈 (제일제당(주) 종합연구소 발효연구팀)
- Published : 1995.12.31
Abstract
In order to find a potent anti-methicillin resistant Staphylococcus aureus (MRSA) antibiotic, actinomycetes isolated from the samples collected in Korean marine silt were screened. From the culture broth of the isolated Streptamyces strain AM045, a substance showing excellent biological activity against MRSA was found, isolated and named AM3. The compound showed strong activities against MRSA, S. epidermidis, E. faecium and E. faecalis, which were better than those of vancomycin and teicoplanin. Unfortunately, AM3 was identified as Actinomycin V. However, this paper reports the three dimensional study of AM3 based on high resolution nmr and Computer Aided Molecular Modeling(CAMM), and the fact that the structure of the pentapeptide lactone ring with oxo-proline in chloroform solution does not have 'C conformation' any more.
항 MRSA 물질을 찾기 위하여 찬국 해양 토양을 검색하였고, 거기서 분리된 방선균의 이차 대사물질 중 항 MRSA 효능을 보이는 물질을 AM3이라고 명명하고 이에 대한 연구를 하였다.