Journal of Pharmaceutical Investigation
- 제25권3호spc1호
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- Pages.33-35
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Development of Local Drug Delivery System: Prolonged Sciatic Nerve Blockade From Biodegradable Microspheres
초록
Microspheres containing tetracaine or bupivacaine with poly-lactic-glycolic acid were prepared with a range of compositions. Using the rat scicatic nerve model in vivo it was found that prolonged blockade for periods of 2-7 days. depending on composition variables. Polymer-local anesthetics microspheres are feasible delivery vehicle for prolonged regional nerve blockade.
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