한국식품과학회지 (Korean Journal of Food Science and Technology)
- 제27권4호
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- Pages.445-448
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- 1995
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- 0367-6293(pISSN)
초산균체 추출물의 In Vitro계 암세포 증식 억제 효과
Cytotoxic Effect of the Extract from Acetobacter aceti OLS-001
- Lee, Byung-Woo (Ottogi Research Center) ;
- Yoo, Yik-Je (Ottogi Research Center) ;
- Yoo, Moo-Yung (Ottogi Research Center) ;
- Hwang, Woo-Ik (College of Medicine, Korea University) ;
- Choi, Chun-Un (Ottogi Research Center)
- 발행 : 1995.08.31
초록
Acetobacter aceti OLS-001 균체에서 추출한 추출물의 농도가 높을수록, 배양시간이 길수록 암세포의 증식 억제 효과가 높게 나타났으며, 현미경 관찰에서 본래의 암세포 형태가 변형되고 세포막사이의 경계막이 흐트러지면서 사멸하는 현상을 나타냈다.
This study was performed to observe cytotoxic effect of Acetobacter aceti OLS-001 extract against cancer cell lines, including mouse leukemic lymphocyte(P388, L1210) and human rectal(HRT-18) cell. The anticancer substance were prepared by ethanol precipitation of the glass bead extraction combined with hot water of Acetobacter aceti OLS-001. The growth rates of the cancer cells in medium containing Acetobacter aceti extract were inhibited gradually to a significant degree in proportion to the increase of the extract concentration. Morphology of HRT-18 cells in medium containing Acetobacter aceti extract were seen to be shrinked and fragmented.