Korean Journal of Oriental Medicine (한국한의학연구원논문집)

Korean Institute of Oriental Medicine (한국한의학연구원)
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The effect of water extract of antler on serum level of female hormone in ovariectomized rats

녹용의 물 추출액 투여가 난소를 절제한 흰쥐의 여성호르몬 변화에 미치는 영향

  • Kim, Mi-Rhyo (Department of Pharmacology, College of oriental medicine, Kyung san University) ;
  • Yang, Chae-Ha (Department of Pharmacology, College of oriental medicine, Kyung san University) ;
  • Kwan, Yong-Zun (College of Pharmacy, Catholic University of Daegu-Hyosung)
  • 김미려 (경산대학교 한의학과 약리학교실) ;
  • 양재하 (경산대학교 한의학과 약리학교실) ;
  • 권용준 (대구 효성 카톨릭 대학교 약학대학 약학과)
  • Published : 1995.10.30
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Abstract

The effect of water extract of antler on serum level of female hormones was investigated in ovariectemized rats. Sprague-Dawley rats were ovariectomized(ox). After a further 40 days the animals were administrated with water extract of antler (625mg/kg daily) for 10, 20 and 30 days, respectively. Serum level of estradiol, progesterone, leutenizing hormone and follicle stimulating hormone were measured. Significant increase of serum estradiol level was elicited at 20 and 30 days after treatment with water extract of antler, respectively, Associated with the increase of serum estradiol level, there was a concomitant decrease in serum follicle stimulating hormone level. Serum progesterone level was also significantly increased at 30 days after treatment with water extract of antler. Although serum leutenizing hormone level of ox rats treated with water extract of anther was slightly lower than that of untreated ox rats, the decrease was not significant.

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