Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Studies on the Effect of Aloe spp. on Ethanol Methabolism (I). -Effect of Aloe vera on Serum Ethanol Level and Hepatic ADH Activity-

Aloe속 식물이 알콜대사에 미치는 작용에 관한 연구(1) -Aloe vera가 알콜 및 알콜대사효소에 미치는 효과-

  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
  • Song, Young-Jin (Natural Products Research Institute, Seoul National University) ;
  • Chung, Ha-Sook (Natural Products Research Institute, Seoul National University) ;
  • Lee, Jung-Mi (R & D Center, Kim Jeong Moon Aloe Co., LTD.) ;
  • Shm, Chang-Sub (R & D Center, Kim Jeong Moon Aloe Co., LTD.)
  • 신국현 (서울대학교 천연물과학연구소) ;
  • 우원식 (서울대학교 천연물과학연구소) ;
  • 송영진 (서울대학교 천연물과학연구소) ;
  • 정하숙 (서울대학교 천연물과학연구소) ;
  • 이정미 ((주)김정문알로에 기술연구소) ;
  • 심창섭 ((주)김정문알로에 기술연구소)
  • Published : 1995.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

As an initial step for evaluating hepatoprotective components against alcohol-induced toxicity, the effect of various fractions from Aloe vera on alcohol metabolism in rats were examined and the results were as follows: Water soluble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic ADH activity. On the other hand, the fractions soluble in organic solvent was found to cause an increase in the blood ethanol concentration and inhibit ADH activity. Further fractionation of the water soluble fraction by ultrafiltration system gave four subfractions corresponding to molecular weight and treatment of them in rats demonstrated that subfraction of M.W. > 30,000 exhibited the most potent enhancing activity of ethanol methabolism.

Keywords