Effect of Polygoni Multiflori Radix on the Atherosclerotic Coronary Artery of Rabbits Induced by High Cholesterol Diet

적하수오(赤何首烏)가 고(高)Cholesterol식이(食餌)에 의하여 유발(誘發)된 가토(家兎) 관상동맥(冠狀動脈)의 죽상경화(粥狀硬化)에 미치는 영향(影響)

In order to evaluate the effect of Polygoni Multiflori Radix on the atherosclerosis induced by high cholesteol diet, rabbits were fed with 4% cholesterol diet, 4% cholesterol-4% Polygoni Multiflori Radix diet during 12 weeks. After 12 weeks, histological changes in coronary artery of rabbits were studied. The results were obtained as follows; 1. At the area % of lumen in coronary arteries, Polygoni Multiflori Radix group showed significant inhibitory effect against decrease of area % in control group. 2. At the atheroma formation in coronary arteries, Polygoni Multiflori Radix group showed decrease effect as compared with control group. 3. At the mucoprotein formation in wall of coronary arteries, Polygoni Multiflori Radix group showed decrease effect as compared with control group. 4. At the lesion of elastic fibers in coronary arteries, Polygoni Multiflori Radix group didn't show effective changes as compared with control group.