The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Study on Local Irritation Test of Bee Venom for Herb-Acupuncture

약침용(藥鍼用) 봉독액(蜂毒液)의 국소독성시험(局所毒性試驗)에 관(關)한 연구(硏究)

  • 이종석 (이종석 한의원) ;
  • 고형균 (경희대학교 한의과대학 침구학교실) ;
  • 김창환 (경희대학교 한의과대학 침구학교실)
  • Published : 1995.04.30
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Abstract

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

Keywords

References

  1. 蜂毒療法과 蜂針療法 金文昊
  2. 毒性學 原理와 試驗方法 金良恒
  3. 奇蹟의 藥鍼療法(1) 金廷彦
  4. 新制養蜂學 崔承允
  5. 鍼灸學 崔容泰(外)
  6. 대한약전 제5개정 1,2부해설 한국약학대학협의회 약전분과회
  7. 毒性學 許仁會(外10人)
  8. 국립안전연구원예규 10호 醫藥品등의 毒性試驗 基準 국립보건안전연구원
  9. 국립보건안전원 예규 제23호 醫藥品등의 安全性 有效性 檢討依賴書 審査에 관한 規定 국립보건안전연구원
  10. 국립보건원예규제222호 一般毒性試驗에 관한 規定 국립보건원
  11. 국립보건원예규 제267호 特殊毒性試驗에 관한 規定 국립보건원
  12. 생물학적 제재기준 및 시험방법개정 發熱性 物質 試驗法 보건사회부
  13. 보건사회부고시 제90-70호 醫藥品등 製造業 및 제조품목 허가지침 보건사회부
  14. 醫藥品安全性 試驗管理 基準 解說書 보건사회부
  15. 대한한의학회지 v.13 no.1 蜂鍼毒 療法이 抗炎 鎭痛 및 解熱에 미치는 效能에 관한 實驗的 硏究 高炯均
  16. 대한침구학회지 v.11 no.1 약침용 봉독액의 급성독성에 관한 연구 고형균(외)
  17. 대한침구학회지 v.10 no.1 蜂鍼毒 療法이 抗痙攣에 미치는 影響 孔賢淑
  18. 경희한의대논문집 v.15 no.1 中脘 및 足三里의 蜂毒療法이 鎭痛 效果에 미치는 影響 李宗錫
  19. 養蜂 協會報 崔大鳳
  20. 中國醫學療法大全 麻仲學
  21. 中國鍼灸學 發展史 莊育民
  22. 實用 中醫辭典 朱文鋒
  23. 雲南中醫雜誌 v.5 張震
  24. 한글판 中西醫結合雜誌 v.4 蜂毒，蜂peptide 抗炎鎭痛，變凝原性 및 急性毒性의 比較 陳維辛(外)
  25. Chemistry and Pharmacology of Honey Bee Venom Barbara;Rudolf
  26. Venom of the Hymenoptera Tom Piek
  27. Scientific reports of the State University in Gorki v.14 Comparative study of the toxic action of bee venom Artemov, N.M.
  28. NAAS Proceedings v.4 The rapid separation of bee venom Components by high pressure liquid chromatography Blasik, M.;Belliveau, J.;Salem, S.;Vivaris, J.;O'Leary, G.
  29. Ann. Allergy v.43 no.2 Enzymes of bee venom, sac and whole body Bousquet, J.;Marty, J.P.;Clauses, C.;Michael, F.B.
  30. Ann. Allergy v.52 no.5 Toxic reactions induced by hymenoptera venom Bousquet, J.;Huchard, G.;Michel, F.B.
  31. JAMA v.231 no.11 Immunotheraphy in bee sting anaphylaxis Busse, W.W.
  32. NAAS Proceeding v.3 The therapelutic effectiveness of bee venom Doyle, L.
  33. J. Pharmacol. Exp. Ther. v.82 Methods for the study of irrition and toxicity of substances applied topically to the skin and mucous membrane Draize, J.H.;Woodard, G.;Calver, H.O.
  34. Proc. Soc. Exp. Biol. Med. v.127 no.3 Antibacterial action of melittin, a polyPeptide from bee venom Fennell, J.F.;Shipman, W.H.;Cole, L.J.
  35. Indian Pediatr v.25 no.8 Acute systemic toxic reactions caused by hornet stings Ghosh, K.;Singh, S.;Pereira, B.J.;Singhi, S.C.
  36. Lancet Lond Anaphylaxis from bee stings Goodman, N.W.
  37. Ergebn. Physiol. v.60 Biochemistry, pharma-cology and toxicology of substances contained in Hymenoptera poisons Haberman, E.
  38. Br. J. Pharmacol. v.50 Anti-inflammatory property of 401(MCD-peptide) a peptide from the venom of bee Hanson, J.M.;Morley, J.;Soria Herrera, C.
  39. Folk Medicine Jarvis, D.C.
  40. Nippon Acta Radiol v.29 no.12 Radioprotection by bee venom Kanno, I.
  41. Toxicon v.15 no.3 Effects of bee venom on the electrocardiogram and blood pressure Kaplinsky, E.
  42. Clin. Ailergy v.10 no.4 IgE antlbodies to bee venom as measured by a modification of the RAST method Kemeny, D.M.;Lessof, M.H.;Trull, A.K.
  43. Influence of the histamine control on skin testing v.47 no.1 Allergy Koller, D.Y.;Pirkre, c.;Jarisch, R.;Gotz, M.
  44. S.Afr.Med.J. v.66 no.8 Bee venom allergy Leaver, R.;Weinberg, E.G.
  45. J. Allergy Clin. Immunol. v.84 no.6 The Hymenoptera venom study. Ⅱ: Skin test results and safety of venom skin testing Lockey, R.F.;Turkeltaub, P.C.;Olive, C.A.;Baird-Warren, I.A.;Olive, E.S.;Bukantz. S.C.
  46. Oftalmol. v.3 Injury of the cornea by bee sting Mozherenkov, V.P.
  47. J. Allergy Clin. Immunol. v.77 no.5 A qualitative and quantitative analysis of proteins found in vespid venoms Mulfinger, L.M.(et al)
  48. J. Allergy Clin. Immunol. v.89 no.2 Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safty Muller, U.;Helbling, A.;Berchtold, E.
  49. Int. Arch. Allergy Appl. Immunol v.68 no.4 Studies of chemically modified honeybee venom I. Bio chemical toxicologic and immunologic Characterization Muller, U.;Reisman, R.;Elliott, W.;Steger, R.;Walsh, S.;Wypych, J.;Arbesman, C.
  50. Acta Pharmacol. Toxicol. v.56 no.2 Hepatotoxicity of hornet's venom sac extract in isolated rat liver Neuman, M.G.(et al)
  51. OECD guidelines for testing of chemical
  52. Folia Med v.10 no.5 Action of the bee's poison on the central nervous system Peitehev, P.
  53. J. of Chromatography v.408 Characterization of bee venom and its main components by high performance liquid chro matography Rader, K.;Wildfeuer, A.;Wintersberger, F.;Bossinger, P.
  54. Rev. Bras. Biol. v.41 no.1 Factors influencing the toxicity and antigenicity of detoxifide Apis mellifera venom Rosario，N.A.(et al)
  55. Toxicon v.18 no.4 Comparative lethality of venoms from stinging hymenoptera Schmidt, J.O.(et al)
  56. Ann. Allergy v.47 no.2 Venom Skin Testing and alteration of RAST levels Schuller, D.Z.(et al)
  57. J. Allergy clin. Immunol v.69 no.4 Diagnosis of insect hypersensitivity Sobotka, A.K.
  58. NAAS Proceeding v.4 Separation of venom components by reverse phase high pressure liquid chromatography Srickle, P.;Harman, A.
  59. Allergy v.47 no.3 Immediate adberse reaction to immunotheraphy in allergy Tamir, R.;Levy, I.;Duer, S.;Pick, A.I.
  60. The action of the bee stings in rheumatism and Gout of tlie Joints Terc, P.
  61. Oftal. zh. v.20 Eyeball injury caused by bee sting Tsvetkov, V.I.
  62. J. Allergy Clin. Immunol. v.73 Insect venom allergy:Diagnosis and treatment Valentine, M.D.
  63. J. Allergy. Clin. Immunol. v.59 no.13 Diagnosis of hymenoptera hypersensitive by skin testing with Hymenoptera venoms Zelenick, L.D.