대한약리학회지 (The Korean Journal of Pharmacology)
- 제31권2호
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- Pages.261-269
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- 1995
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- 0377-9459(pISSN)
Aspartate 및 Asparagine 투여가 알코올 대사 및 중추신경계 효과에 미치는 영향
Effect of Aspartate and Asparagine on Metabolism and Central Nervous System Effect of Alcohol in Healthy Male Volunteers
- 임동석 (서울대학교 의과대학 약리학교실) ;
- 이경훈 (서울대학교 의과대학 약리학교실) ;
- 장인진 (서울대학교 의과대학 약리학교실) ;
- 신상구 (서울대학교 의과대학 약리학교실) ;
- 이윤성 (서울대학교 의과대학 법의학교실) ;
- 박상철 (서울대학교 의과대학 생화학교실)
- Yim, Dong-Seok (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Lee, Kyung-Hun (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Jang, In-Jin (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Shin, Sang-Goo (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Lee, Yoon-Sung (Department of Forensic Medicine, College of Medicine, Seoul National University) ;
- Park, Sang-Chul (Department of Biochemistry, College of Medicine, Seoul National University)
- 발행 : 1995.09.30
초록
Background; To explore the efficacy of aspartate as NAD regenerating agent for ethanol and acetaldehyde oxidation, we performed crossover challenge in two groups of volunteers by coadministration of various doses of aspartate, asparagine and ethanol. Methods; 18 healthy male volunteers were randomly divided into two groups. 6 volunteers of the first group were administered 5 gm monosodium aspartate(MSA), 5 gm asparagine or placebo with 100 ml of