Archives of Pharmacal Research
- Volume 18 Issue 3
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- Pages.206-212
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- 1995
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Biological Activity of Indazole-Derived HMG-CoA Reductase Inhibitors
- Kim, Jin-Il (College of Pharmacy, Yeungnam University) ;
- Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
- Published : 1995.06.01
Abstract
New hypolipaemic agents, in which substituted indazole nucleus is connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to show significant inhibitory activity against microsomal HMG-CoA reductase in rat liver.