The Korean Journal of Physiology
- Volume 29 Issue 2
- /
- Pages.291-299
- /
- 1995
- /
- 0300-4015(pISSN)
Enhanced Efficacy of the Commissural Transmission between Lateral Giants in the Sensitization of Crayfish Escape Behavior
- C.Lee, Sun-Hee (Department of Physiology, College of Medicine, Dongguk University)
- Published : 1995.12.30
Abstract
Lateral giant (LG)-mediated escape response of crayfish is sensitized by natural traumatic events. Such sensitization has previously been shown to be associated with increased transmission between primary afferents and sensory interneurons at the cholinergic synapse of LG escape reflex circuit. In the present study, it was firstly investigated as to whether transmission is also altered at other synapses of the LG-escape reflex circuit by traumatic shock-induced sensitization. Evidence that traumatic shock also directly affects the excitability of lateral giants is now provided by the finding that traumatic shock produces a significant reduction of the time needed for LG to recruit its contralateral homologue, which is defined as commissural delay. Octopamine, a naturally occurring neuromodulator in the crayfish nerve cord, has also been shown to enhance transmission at the cholinergic synapse between primary afferents and sensory interneurons, and has been conjectured to mediate sensitization. Like traumatic shock,
Keywords