The Korean Journal of Physiology
- 제29권2호
- /
- Pages.225-232
- /
- 1995
- /
- 0300-4015(pISSN)
Phorbol Ester-Induced Periodic Contraction in Isolated Rabbit Jugular Vein
- Ryu, Jae-Cheol (Department of Physiology, College of Medicine, Pusan National University) ;
- Jung, Dong-Keun (Department of Physiology, College of Medicine, Pusan National University) ;
- Lee, Sang-Ho (Department of Physiology, College of Medicine, Pusan National University)
- 발행 : 1995.12.30
초록
The present study was conducted to evaluate the effect of phorbol 12,13-dibutyrate (PDBu) on the contraction of rabbit jugular vein in vitro. PDBu concentrations of greater than 10 nM induced a periodic contraction which was composed of rapid contraction, plateau and slow relaxation. The frequency of periodic contraction increased as PDBu concentration increased. The PDBu-induced contraction was inhibited by staurosporine (100 nM), it was not changed by tetrodotoxin