The Korean Journal of Physiology
- Volume 29 Issue 1
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- Pages.61-67
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- 1995
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- 0300-4015(pISSN)
The Action of Ginkgo Bibloba Extract in the Isolated Rabbit Corpus Cavernosum
- Chung, Woo-Sik (Department of Urology, Ewha Womans University College of Medicine) ;
- Choi, Young-Deuk (Department of Urology, Ewha Womans University College of Medicine) ;
- Park, Young-Yo (Department of Urology, Ewha Womans University College of Medicine) ;
- Hah, Jong-Sik (Department of Physiology, Ewha Womans University College of Medicine)
- Published : 1995.06.30
Abstract
The extract of Ginkgo bibloba (EGb) is a complex mixture of natural products from the Ginkgo leaves and clinically used for the treatment of cerebral and peripheral circulatory disturbances due to its combined activity of several vasoactive principles. In this study we investigated the action of EGb and its mechanism in isolated rabbit corporal smooth muscle to evaluate the possibility of using this material as a pharmacoerecting agent. Strips of rabbit corpus cavernosum were mounted in organ chambers to measure isometric tension. EGb began to exert an relaxing effect at 1 mg/ml in the submaximally precontracted muscle strips with phenylephrine