Applied Chemistry for Engineering (공업화학)
- Volume 5 Issue 1
- /
- Pages.176-181
- /
- 1994
- /
- 1225-0112(pISSN)
- /
- 2288-4505(eISSN)
Biochemical Resolutions of Organic Florine Compounds Using Lipase
Lipase를 이용한 함불소화합물의 광학분할
-
Son, Tae-Il
(Dept. of Biotechnology, Studies of Ind., ChungAng Univ.)
;
- Kitazume, Tomoya (Dept. of Bioengineering, Tokyo Inst. of Tech.)
- Received : 1993.11.03
- Accepted : 1993.11.29
- Published : 1994.02.01
Abstract
The hydrolysis of biochemical kinetic resolutions for 2-[1-(acetoxy-2, 2, 2-trifluoroethyl)]-5-trimethylsilylfuran(1) using kinds of Lifase(talpase, paratase, M1000L, SP398, SP435) was investigated. In the results SP435 of Novo Nordish comp any was confirmed to show the capacity of biochemical kinetic resolutions, and 2-(1-(2, 2, 2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2) to have the optical purity expressed as 92.4% enantiomeric excess(ee) was produced in this studies.
시판되고 있는 4종류의 Lipase(talpase, paratase M1000L, SP398, SP435)를 이용하여, 2-[1-(1-acetoxy-2, 2, 2-trifluoroethyl)]-5-trimethylsilylfuran(1)을 속도론적 광학분할에 의해서 가수분해반응을 검토했다. 그 결과 Novo Nordish사의 SP435가 속도론적 광학분할능을 가진다는 것을 확인했으며, 본 실험에서는 광학순도 92.4% enantiomeric excess(ee)를 가지는 생성물 2-[1-(2, 2, 2-trifluoro-1-hydroxyethyl)]-5-trimethylsilyfuran(2)를 얻었다.
Keywords