Applied Microscopy
- Volume 24 Issue 3
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- Pages.23-33
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- 1994
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- 2287-5123(pISSN)
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- 2287-4445(eISSN)
A Study on the Ultrastructural Changes of Cardiac Muscle in Dichlorvos Treated Albino Rat
Dichlorvos가 흰쥐 심근의 미세구조에 미치는 영향
- Baik, Tai-Kyoung (Department of Anatomy, Hanyang University, College of Medicine) ;
- Lee, Wha-Mo (Department of Anatomy, Hanyang University, College of Medicine) ;
- Chung, Ho-Sam (Department of Anatomy, Hanyang University, College of Medicine)
- Published : 1994.09.01
Abstract
It is well known that dichlorvos (DDVP), an organophosphate insecticide in common use, is so easily and rapidly hydrolyzed and excreted that it has usually little toxic effect on human body. In these days, however, it is widely used as an industrial and domestic insecticide and as an anthelmintic agent for animals, so that the accident of chemical poisoning occurs frequently. DDVP acts as a powerful inhibitor of carboxylic esterase, which can cause accumulation of acetylcholine at the synapses so paralysis of muscle and the transmission failure in cholinergic synapses dueing to desensitization of acetylcholin receptor may occure. Moreover accumulation of the acetylcholine brings about the elevation of the cyclic-AMP, which alters the cellular metabolisms of nucleic acid, carbohydrate, protein and lipid. Present study has undertaken to investigate the cardiotoxic effect of DDVP by electron microscopic study. A total of 30 Sprague-Dawley strain rats, weighing about 250gm were used as experimental animals. 2mg/kg/day of DDVP is intraperitonealy injected 3 times with intervals of every other day. On 1 day, 3 days, 5 days, 7 days and 14 days after drug administration, the animals were sacrified by cervical dislocation. Left ventricular cardiac muscles were resected and sliced into