Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesis of Peptides Containing Optically Active 2-Amino-3-Phosphonopropionic Acid

광학 활성 2-Amino-3-Phosphonopropionic Acid의 새로운 합성 방법과 그를 포함하는 펩티드의 합성

  • Kim Sang Bum (Department of Chemical Engineering, Korea University) ;
  • Cho Sung Ki (Department of Chemical Engineering, Inje University) ;
  • Han Jeong Sik (Korea Research Institute of Chemical Technology) ;
  • Kim Yong Joon (Department of Chemical Engineering, Korea University) ;
  • Hong Suk-In (Department of Chemical Engineering, Korea University)
  • 김상범 (고려대학교 공과대학 화학공학과) ;
  • 조성기 (인제대학교 공과대학 화학공학과) ;
  • 한정식 (한국화학연구소) ;
  • 김용준 (고려대학교 공과대학 화학공학과) ;
  • 홍석인 (고려대학교 공과대학 화학공학과)
  • Published : 19940700
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Abstract

New synthetic method of optically active 2-amino-3-phosphonopropionic acid from L-serine was developed and their phosphonotripeptides, phthalylglycylglycyl-2-amino-3-(diethylphosphono)-propionic acid methyl ester and phthalylglycyl-L-phenylalanyl-2-amino-3-(diethylphosphono)propionic acid methyl ester, were synthesized by coupling reaction of amino acids with 2-amino-3-phosphonopropionic acid methyl ester.

L-serine으로부터 광학 활성을 가지는 2-amino-3-phosphonopropionic acid를 새로운 방법으로 합성하였으며 2-amino-3-(diethylphosphono)-propionic acid methyl ester를 아미노산과 축합시켜 광학 활성을 갖는 새로운 포스포노트리펩티드를 합성하였다.

Keywords

References

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