Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Resistance of Kanamycin- and Neomycin-Producing Streptomycetes to Aminoglycoside Antibiotics

  • Goo, Yang-Mo (Department of Pharmacy, Seoul National University) ;
  • Choi, Seok-Rye (Department of Pharmacy, Seoul National University) ;
  • Kim, Kyung-Ja (Department of Genetics, Soonchunhyang University)
  • Published : 1994.07.20
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Abstract

Streptmyces fradiae NRRL B1195 and Streptomyces kanamyceticus IFO 13414 are highly resistant to the antibiotics they produce. The ribosomes of these organisms are found to be susceptible to the antibiotics, but the cell free extract of S fradiae is found to contain a phosphotransferase and an acetyltransferase which inactivate kanamycin and neomycin, and that of S. kanamyceticus an acetyltransferse which inactivates kanamycin and neomycin. The resistance of these organisms against streptomycin is found to be due to the resistant ribosomes; actually streptomycin activates their ribosomal systems for the synthesis of polyphenylalanine.

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References

  1. Ann. Rev. Microbiol. v.32 Davies, J.;Smith, D. I.
  2. Brit. Medical. Bull. v.40 Phillips, I.;Shannon, K.
  3. Biochem. Biophys. Res. Commun. v.100 Yamamoto, H.;Hotta, K.;Okami, Y.;Umezawa, H.
  4. J. Antibiot. v.35 Yamamoto, H.;Hotta, K.;Okami, Y.;Umezawa, H.
  5. J. Antibiot. v.36 Murakami, T.;Nojiar, C.;Toyama, H.;Hayashi, E.
  6. J. Antibiot. v.157 Nakano, M.;Mashiko, H.;Ogawara, H.
  7. J. Antibiot. v.34 Yamamoto, H.;Hotta, K.;Okami, Y.;Umezawa, H.
  8. Infect. Immuno. v.1 Benveniste, R.;Yamada, T.;Davies, J.
  9. Ann. N. Y. Acad. Sci. v.182 Davis, J.;Brazerzinska, M.;Benveniste, R.
  10. Antimicrob. Agents Chemother. v.4 Haas, M. J.;Davies, J.
  11. J. Bacteriol. v.100 Ozanne, B.;Benveniste, R.;Tipper, D.;Davies, F.
  12. FEBS Lett. v.110 Sugiyama, M.;Kobayashi, H.;Nimi, O.;Nomi, R.
  13. J. Gen. Microbiol. v.121 Sugiyama, M.;Nimi, P.;Nomi, R.

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  1. Kanamycin Acetyltransferase Gene from Kanamycin-producing Streptomyces kanamyceticus IFO 13414 vol.21, pp.4, 1998, https://doi.org/10.1007/bf02974645