Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Transition-Metal-Mediated Cytotoxicity of Quinolones to L1210 Cells

  • Ko, Tong-Sung (Department of Biochemistry, Chungnam National University) ;
  • Kwon, Tae-Ik (Department of Biochemistry, Chungnam National University) ;
  • Kim, Moon-Jip (Department of Physics, Soonchunhyang University) ;
  • Park Il-Hyeon (Department of Biochemistry, Chungnam National University) ;
  • Ryu Hyeong-Won (Department of Biochemistry, Chungnam National University)
  • Published : 1994.06.20
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Abstract

Transition metals tested, $Cu^{2+}$, and $Ni^{2+}$, were found effective in the induction of the cytotoxicity of the quinolones tested, nalidixic acid, oxolinic acid, and pipemidic acid, against L1210 leukemia cells in vitro, whereas the alkaline earth metal, $Mg^{2+}$, was not. The differential effect of the metals on the quinolone cytotoxicity can be explained by their different mode of interaction with the quinolones. Our present difference spectroscopic titration data suggest that the transition metals can form DNA-intercalating agents, with the quinolones, which can cause the cytotoxicity.

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