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Transition-Metal-Mediated Cytotoxicity of Quinolones to L1210 Cells

  • Ko, Tong-Sung (Department of Biochemistry, Chungnam National University) ;
  • Kwon, Tae-Ik (Department of Biochemistry, Chungnam National University) ;
  • Kim, Moon-Jip (Department of Physics, Soonchunhyang University) ;
  • Park Il-Hyeon (Department of Biochemistry, Chungnam National University) ;
  • Ryu Hyeong-Won (Department of Biochemistry, Chungnam National University)
  • 발행 : 1994.06.20

초록

Transition metals tested, $Cu^{2+}$, and $Ni^{2+}$, were found effective in the induction of the cytotoxicity of the quinolones tested, nalidixic acid, oxolinic acid, and pipemidic acid, against L1210 leukemia cells in vitro, whereas the alkaline earth metal, $Mg^{2+}$, was not. The differential effect of the metals on the quinolone cytotoxicity can be explained by their different mode of interaction with the quinolones. Our present difference spectroscopic titration data suggest that the transition metals can form DNA-intercalating agents, with the quinolones, which can cause the cytotoxicity.

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참고문헌

  1. J. Med. Chem. v.11 Kaminsky, D.;Meltzer, R. I.
  2. Bioinorganic Chemistry v.9 Timmers, K.;Sternglanz, R.
  3. Korean Biochem. J. v.24 Ryu, H.-W.;Oh, B.-K.;Suh, J.-I.;Song, C.-W.;Ko, T.-S.
  4. J. Korean. Chem. Soc. v.34 Oh, B.-K.;Suh, J.-I.;Ryu, H.-W.;Ko, T.-S.
  5. Biochemistry v.27 Drlica, K.;Franco, R.
  6. Biochemistry v.24 Pommier, Y.;Schwartz, R. E.;Zwelling, L. A.
  7. Biochemistry v.24 Pommier, Y.;Minford, J. K.;Schwartz, R. E.;Zwelling, L. A.;Kohn, K. W.
  8. Proc. Natl. Acad. Sci. U. S. A. v.81 Nelson, E. M.;Teway, K. M.;Liu, L. F.
  9. J. Biol. Chem. v.259 Tewey, K. M.;Chen, G. L.;Nelson, E. M.;Liu, L. F.
  10. Science v.226 Tewey, K. M.;Rowe, T. C.;Yang, L.;Haligan, B. D.;Liu, L. F.
  11. Biochemistry v.20 Zwelling, L. A.;Michaels, S.;Brickson, L. C.;Ungerleider, R. S.;Nichols, M.;Kohn, K. W.
  12. Cancer Res. Id v.42 Zwelling, L. A.;Kerrigan, K.;Michaels, S.
  13. Biochim. Biophys. Acta. v.519 Ross, W. E.;Glaubiger, D. L.;Kohn, K. W.
  14. Biochim. Biophys. Acta. v.562 Ross, W. E.;Glaubiger, D. L.;Kohn, K. W.
  15. J. Mol. Biol. v.27 Lepecq, J. B.;Paoletti, C.
  16. Cancer Chemother. Rep. Thayer, P. S.;Himmelfarb, P.;Watt, G. L.
  17. Cell Culture Technical Procedures National Cancer Institute USA
  18. Solution Equilibria Hartley, F. R.;Burgess, C.;Alcock, R. M.
  19. MS Thesis Structural Polymorphism of Nalidixic Acid Related to Physiological Activity Park, J. K.
  20. Biochem. Pharmacol. v.34 Ross, W. E.
  21. The New Generation of Quinolones Wetland, M. P.;Siporin, C.(ed.);Heifetz, C. L.(ed.);Domagala, J. M.(ed.)
  22. N. Engl. J. Med. v.324 Hooper, D. C.;Wolfson, J. S.
  23. Antimicrob. Agents Chemother v.33 Chu, D. T. W.;Ferrandts, P. B.
  24. J. Biol. Chem. v.267 Elsea, S. H.;Osheroff, N.;Nitiss, J. L.
  25. J. Biol. Chem. v.266 Robinson, M. J.;Martin, B. A.;Gootz, T. D.;McGuirk, P. R.;Moynihan, M.;Sutcliffe, J. A.;Osheroff, N.
  26. Antimicrob. Agents Chemother. v.36 Robinson, M. J.;Martin, B. A.;Gootz, T. D.;McGuirk, P. R.;Osheroff, N.