Biomolecules & Therapeutics
- 제2권1호
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- Pages.47-53
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- 1994
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
단백질메칠화 반응과 간독성간의 상관관계
Correlation between Protein Methylation and Hepatotoxicity
초록
The methylation response as well as the level of methyl donor substance, 5-adenosyl-L-methionine (SAM) has been suggested to be related to hepatotoxicity including hepatocarcinogenesis. But direct correlation between protein methylation and hepatotoxicity has not been established to the present. To observe relationship between protein methylation and short-term hepatotoxicity induced by chemical substances, the activities of protein methylase I and II (PM I, PM II) were examined in cytosolic fraction of SD rat treated orally with acetaminophen(AA),
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