The Korean Journal of Applied Statistics (응용통계연구)

The Korean Statistical Society (한국통계학회)
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An Overview of Group Sequential Procedures

집단축차검정법들에 관한 고찰

  • Jae Won Lee (Department of Statistics, Korea University, Anamdong 5-1, Sungbukku, Seoul 136-701, Korea)
  • Published : 1994.09.01
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Abstract

For ethical and economic reasons, clinicla trials must be repeatedly monitored for evidence of treatment benefit or harm. Repeated testing at conventional critical values can substantially inflate the overal type I error rate. To maintain acceptable levels, group sequential procedures have been developed for clinical trials. This article gives a brief overview of the group sequential procedures.

윤리적 또는 경제적 이유 때문에 임상실험(Clinical Trials)의 연구자들은 실험중간에 새로운 치료방법이나 약이 효과가 있는지 또는 해로운지를 반복해서 검정한다. 하지만 각 검정마다 정해진 유의수준을 반복해서 사용하면 전체 유의수준이 상당히 커지게 된다. 임상실험에서 발생하는 이러한 문제를 해결하기 위하여 많은 집단측정검정법 (Group Sequential Testing Procedure)들이 개발되어 왔다. 본 논문에서는 이러한 집단측정검정법들을 간략하게 비교분석하고자 한다.

Keywords

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