Journal of Nutrition and Health
- 제27권5호
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- Pages.419-428
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- 1994
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- 2288-3886(pISSN)
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- 2288-3959(eISSN)
지방질원으로서 어유가 백서 상피세포의 인지질 조성 및 Protein Kinase C 활성에 미치는 영향
Effect of Menhaden Oil Feeding on Protein Kinase C Activity and Membrane Phospholipid Profiles in Mouse Epidermal Cells
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최면
(강원대학교 축산대학 축산가공학과)
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Choe, Myeon
(Department of Animal products Science, College of Animal Agriculture, Kangweon National University)
- 발행 : 1994.06.01
초록
To investigate the effect of dietary menhaden oil on protein kinase C (PKC) activity and membrane phospholipid composition in epidermal cells, female BALB/C mice were fed either menhaden oil or corn oil with two different levels(5% or 20%) for 6 weeks. Membrane phosphatidycholine(PC) was decreased in menhaden oil-fed group. Eicosapentaenoic acid(EPA) and Docosahexaenoic acid(DHA) were only presented in the acyl chain of membrane phospholipid of menhaden oil-fed mice, so that membrane fluidity of the group could be different from the other group. Both cytosolic and membrane-associated PKC activity in epidermal cells were decreased in menhaden oil-fed mice when compare with corn oil-fed mice. Furthermore, rate of PKC transfer from cytosol to membrane in menhaden oil-fed group was not as fast as in corn oil-fed group. Based on these observations, dietary menhaden oil might act differently from other dietary fat in carcinogenesis.