Ganoderma lucidum IY 009조다당 분획들의 항암활성과 항보체활성간의 상호관계

Correlation between Anticomplementary and Antitumor Activity of the Crude Polysaccaride from Ganoderma Iucidum IY009

  • 이권행 (연세대학교 식품공학과) ;
  • 이준우 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 한만덕 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 정훈 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 김영일 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 오두환 (연세대학교 식품공학과)
  • Lee, Kweon-Haeng (Department of Food Engineering, College of Engineering, Yonsei university) ;
  • Lee, June-Woo (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Han, Man-Deuk (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Jeong, Hoon (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Kim, Young-Il (Biotechnology Lab., Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Oh, Doo-Whan (Department of Food Engineering, College of Engineering, Yonsei university)
  • 발행 : 1994.02.01

초록

Antitumor polysaccharides were known to activate complement system and to increase specific serum proteins in mouse, and researcher reported that antitumor activity of polyasccharides might be correlated with their biological properties such as activation of complement system and increase of specific protein $L_{A}$, $L_{B}$ and $L_{C}$ within the mouse serum. In case of several Ganoderma lucidum, there was no correlation between their antitumor activities and their bioloical properties, but the antitumor activities against sarcoma 180 of the alkali extracted crude polysaccharide fractions of the Ganoderma lucidum IY 009. AS, T, AI and M were correlated with their bioloical properties such as anticomplementary activity and intensity of mouse serum protein $L_{A}$, $L_{B}$ and $L_{C}$.

키워드

참고문헌

  1. 新編 生物活性天然物質 紫田承二
  2. Planta Med. v.55 Polysaccherides in phamacy: current applications and future concepts Franz,G.
  3. Cancer Res. v.37 Conynebacterium parvum and cyclophosphamide as combination treatment for a murine mammary adenocarcinoma Purnell,D.;G.Bartlet;J.Kreider;T.Brio
  4. Cancer Treat. Rep. v.62 Combination chemotherapy plus methanol extracted residue of Bacillus Calmette-Guerin of Corynebacterium paryum in stage Ⅲ lung cancer Bjorsson,S.;H.Takida;N.Kuberta;H.Preister;D.Higby;E.Henderson
  5. Nature New Biol. v.243 On the mode action of BCG Michell,R.G.;D.Kirkpatrick;B.Mokyr;I.Gevy
  6. Cancer v.43 Adjuvant immunotheraphy of lung cancer with BCG cell-wall skeleton(BCG-CWS) Yamaura,Y.M.;Sakatani,T.;Ogura;I.Azuma
  7. Cancer Res. v.44 Inhibition of pulmonary metastasis by Nocardia rubra cell wall skeleton. with special reference to macrophage activation Kagawa,K.;T.Yamashita;E.Tsubura;Y.Yamamura
  8. Cancer Res. v.30 Fractionation and purification of the polysaccharides with marked antitumor activaty. especially lentinan from Lentinus edodes (Berk)Sing Chihara,G.;J.Hamuro;Y.Maeda;Y.Arai;F.Fukuoka
  9. Gann. v.65 Protein-bound polysaccharide preparation. PS-K. effective against mouse sarcoma-180 and rat ascites hepatoma AH-13 by oral use Tsukagoshi,S.;F.Ohashi
  10. Carbohydr. Res. v.69 Relationship between the chemical structure and antitumor activity of glucan prepared from Grifola umbellata Miyazaki,T.;N.Oikawa;T.Yadomac;H.Yamada;H.Hong-Yen;H.Ito
  11. Chem. Pharn. Bull. v.37 Antitumor and immunomodulationg activities of a β-glucan obtained from liquid-cultured Grifola flondosa Suzuki,I.;K.Hashimoto;S.Oikawa;K.Sato;M.Osawa.M.;T.Yadomae
  12. Tokyo Yakka Daigaku Kenkyu Nempo v.27 Toxicological studies of Ganoderma Iucidum Karst Sugiura,M.;H. Ito, H.
  13. Nature New Biol. v.238 Anticomplementary activity of antitumor polysaccharides Okuda,T.;Y.Yoshioka;T.Ikekawa;G.Chihara;K.Nishioka
  14. Japan J. Pharmacol. v.40 Effects of the antitumor agents from various natural sources on drug-metabolizing system. phagocytic activity and complement system in sarcoma 180-bearing micc Ito,H.
  15. schizophyllan v.32 Pharmacological and toxicological studies of a new antitumor polysaccharide Matsu,T.;T.Arika;M.Mitani;N.Komatsu
  16. 한국생화학회지 v.14 한국산 담자균류의 항암성분에 관한 연구 강창률;심미자;최응칠;이영남;김병각
  17. Planta Med. v.50 Studies on polysaccarides from Angelica acutiloba Yamada,H.;H.Kiyohara;J.C.Cyong;Y.Kojima;Y.Kumazawa;Y.Otsuka
  18. Anal. Chem. v.28 Colorimetric method for determination of sugars and related substances Duboise,M.;K.A.Gilles;J.K.Hamilton;P.A.Rebers;F.Smith
  19. Anal. Biochem. v.150 Measurement of protein using bicinchoninic acid Smith,P.K.;R.L.Krohn;G.T.Hermanson;A.K.Mallia;F.H.Gartner;M.D.Provenzano;E.K.Fujimoto;N.M.Goeke;B.J.Olson;D.C.Klenk
  20. Immunol. v.34 Solid phase activation of alternative pathway of complement by β-1,3-glucans and its posible role for tumor regressing activity Hamuro,J.;U.Hadding;D.Bitter-Suermann