Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지

In Vivo Blood Compatibility of PU-PEO-SO3 as Coating Material for Blood Sac of Left Ventricular Assist Device ( LVAD)

좌심실보조장치의 혈액주머니용 코팅재료로서 PU-PEO-SO3의 in vivo 혈액적합성에 관한 연구

  • 한동근 (한국과학기술연구원 고분자화학팀) ;
  • 김종원 (서울대학교 의과대학 의공학교실, 한국과학기술연구원 고분자화학팀)
  • Published : 1994.03.01
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Abstract

Sulfonated poly (ethyleneoxide)-grafted polyurethane (PU-PEO-$SO_3$) prepared by bulk modification was coated on a blood sac for electrohydraulic left ventricular assist device (ELVAD) implanted in dogs and its in vivo blood compatibility on shear stress was studied as compared with untreated Po. The effect of the wall shear stress on the protein adsorption unlike platelet adhesion is dependent on the surface characteristics of the material, although less proteins seem to be adsorbed in the region of the high shear stress. The thickness of total proteins adsorbed on PU-PEO-SOJ (400 ${\AA}$) by trans¬mission electron microscopy(TEM) was considerably lower than that of untreated PU(l,000~1,600 ${\AA}$), but PU-PEO-$SO_3$ showed high albumin adsorption, low fibrinogen and IgG adsorption, and low platelet adhesion as compared with untreated PU, suggesting that PU-PEO-$SO_3$ is more in vivo blood compatible. Therefore, it appears that such a blood compatible PU-PEO-$SO_3$ is useful for blood contacting biomaterials including artificial organs.

Keywords

References

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