Archives of Pharmacal Research

  • 제17권6호
  • /
  • Pages.480-482
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  • 1994
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

5-Substituted Pyrimidine Acyclis Nucleoside Analogues 1-Cyanomethyl- and 1-(4-Cyanobutyl)-5-substituted Uracils as Candidate Antitumor Agents

  • Kim, Jack-C. (Department of Chemistry, College of Natural Science) ;
  • Dong, Eun-Soo (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Park, Jin-Il (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Bae, Sang-Duk (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Kim, Seon-Hee (Department of Biochemistry, College of Medicine, Pusan University)
  • 발행 : 1994.12.01
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초록

A number of 5-substituted pyrimidine acyclic nucleosides were synthesized and tested for invitor cytotoxicity against four cell lines (j-82 cell, p-388 cell, FM-3A cell and U-938 cell lines). Synthesis of 1-cyanomethyl-5-substituted pyrimidines (1a-e) and 1-(4-cyanobutyl)-5-substituted pyrimidines (2a-e) was acomplished from the series of alkylation reactions ofl 5-substituted uracils with the corresponding chloacetonitrile and 5-chlorovaleronitile in DMSO under $50^{\circ}C$ temperature. These 5-substituted pyrimidine acylic nucleosides (1a-e and 2a-e) exhibited moderate to significant acitivity aginst four cell lines.

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참고문헌

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