Archives of Pharmacal Research

  • 제17권6호
  • /
  • Pages.434-437
  • /
  • 1994
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis of Dibenzoylmethanes as Intermediates for Flavone Synthesis by a Modified Baker-Venkataraman Rearrangement

  • 발행 : 1994.12.01
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초록

1-Polyoxyphenyl-3-(2, 6-dioxyphenyl)propane-1, 3-diones have been synthesized as intermediates for flavone synthesis by condensation of 2-(2, 6-dioxybenzoyloxy)polyoxyacetophenone in the presence of phae transfer catalyst. The average yields of 1-polyoxyphenyl-3-phenylpropane-1, 3-diones, 1-polyoxyphenyl-3(2-benzyloxyphenyl)propane-1, 3-diones and 1-polyoxy-3-(2, 6-dibenzyloxyphenyl)propane-1, 3-dions were 79%, 74% and 71% respectively. The bulkiness of the benzyloxy groups or methyoxy gorups exerted steric hindrance and reduced the yield. Nevertheless, the yield were higher than the previously reported ones.

키워드

참고문헌

  1. J. Chem. Soc. v.a1 Baker,W.
  2. Yakhak-Hoeji v.32 no.2 Synthesis of Geranyloxyflavone Derivatives and Their Antitumor Activity on L1210 and Sarcoma 180 cells Baik,K.U.;Ahn,B.Z.
  3. Tetrahedron Letters. v.37 On the Structure of Zapotin adn ZapotininⅡ. The Synthesis of Zapotin Farkas,L.;Gottsegen,A.;N$\'{o}gr$\'{a}$di,M.
  4. Current Sci.(India) v.2 Mahal,H.S.;Venkataraman,K.
  5. J. Chem. Soc. v.1967 Mahal,H.S.;Venkataraman,K.
  6. Yakhak Hoeji. v.38 Synthesis of 2-Aroyloxyace-tophenones as Intermediates for Flavone Synthesis Song,G.Y.;Ahn,B.Z.
  7. Phase Transfer Catalysis in Organic Chemistry Weber,W.P.;Gokel,G.W.