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The Pharmaceutical Society of Korea (대한약학회)
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Studies of Complex Formation between the Bromophenol Blue and some Important Aminoquinoline Antimalarials

  • Published : 1994.12.01
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Abstract

A simple nad rapid colorimetric method for the assay of amodiaquine hydrochloride, chloroquine phosphate and primaquine phosphate is described. The method is based on the interaction of the drug base with bromophenol blue to give a ion-pair complex. The spectra of the complex shows a maxima at 415-420 nm with high apparent molar absorptivities. Beer's law was obeyed in the concentration range 1-8, 2-10 and $2-12{\;}{\mu}{\cdot}ml^{-1}$ for amodiaquine hydrochloride, primaquine phosphate and chloroquine phosphate respectively. The proposed method was applied to the determination of these drugs in certain formulations and the results were favourably comparable to the official methods.

Keywords

References

  1. J. Pharm.Belg. v.41 Utility of charge-trangfer complex formation for spectrophotometric detrmination of some antimalarials Abdel-Salam,M.;Issa,A.S.;Lymona,H.
  2. Analyst v.105 Spctrophotometric deternimation of primaquine phosphate in pharmaceutical preparation Abou-Ouf,A.A.;Hassan,S.M.;Metwally,M.E.
  3. J. Pharm. Pharmacol. v.32 Improved fluorimetric assay of chloroquine in biological samples Adelusi,S.A.;Salako,L.A.
  4. British Pharmacopoeia
  5. Phrmazie v.41 lon-pair spectrophotometric assay of oxolamine Buyuktimkin,N.;Buyuktimkin,S.
  6. Alexandria J. Pharm. Sci. v.2 Spectrophotometric determination of amodiaquine hydrochloride using 2,2-diphenyl-1-picrylhydrazyl Emara,K.M.
  7. Mikrochem. Acta. v.1 Spectrophotometric determination of some pharmaceutically important aminoquinoline antimalarials Ibrahim,F.A;El-Brashy,A.M.;Belal,F.
  8. Microchem. J. v.39 Fluorometric determination of som aminoquinoline antimalarials using Eosin Ibrahim,F.A.;Belal,F.;El-Brashy,A.
  9. Spectrochemical Methods of Analysis v.9 Job,P.
  10. Talanta v.33 Colorimetric determination of some antimalarials Mahrous,M.S.;Abdel-Salam,M.;Issa,A.S.;Abdel-Hamid,M.
  11. Analyst v.115 Determination of diphenylhydramine hydrochloride by flow injection with bromophenol blue and turbidimetric measument Martinez,C.J.;Sanchez,S.A.;Navasquillo,S.S.
  12. Indian Drugs v.27 Spectrophotometri determination of amodiaquine hydrochloride in dosage forms Rao,G.R.;Murty,S.S.N.;Raju,I.R.K.
  13. Indian Drugs v.23 Extractive spectrophotometric method for determination of ranitidine hydrochloride from pharmaceutical preparations Sadana,G.S.;Sane,R.T.;Ozarkar,S.G.;Spare,D.S.;Nayak,N.G.
  14. Statistics Sanders,D.H.;Murph,A.F.;Eng,R.J.
  15. Analyst v.115 Determination of amodiaquine in pharmaceuticals by reaction with periodate and spectrophotometry or by high performance liquid chromatography Sanghi,S.K.;Verma,A.;Verma,K.K.
  16. Indian Drugs v.24 Extractive spectrophotometric determination of some antimalarials using fast green Sastry,B.S.;Rao,E.V.;Tummura,M.K.;Sastry,C.S.P.
  17. Indian J. Pharm. Sci. v.51 Estimation of some aminoquinoline antimalarials using tannic acid Sastry,B.S.;Rao,J.V.;Prasad,T.N.V.;Sastry,C.S.P.
  18. Indian Durgs v.25 Extractive spectrophotometric method for determination of flufenamine hydrocholoride from its tablets Shingbal,D.M.;Kara,R.
  19. The United States Pharmacopoeia XXII, National Formularly XVII USP Conventiona, Inc
  20. Anal Lett. v.16 Determination of some quinoline derivatives with organic brominating agents Walash,M.I.;Rizk,M.;Abou-Ouf,A.A.;Belal,F.
  21. Anal. Chim. Acta v.228 Simultaneous determination of chloroquine and selected calcium channel blockers by high performance liquid choromatography Williams,H.L.;Johnson,D.J.;Collins,H.H.;Martin,S.K.;Ramuz,H.
  22. Indian Drugs v.24 Simple extractive colorimetric determination of pipazethate hydrochloride from pharmaceutical preparations Zarapker,S.S.;Rele,R.V.;Shah,V.M.