Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Angiotensin Il-Mediated Stimulation of Phospholipase D in Rabbit Kidney Proximal Tubule Cells

  • Published : 1994.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The present study was undetertaken to demonstrate whether or not angiotensin II activates a phopholipase D in rabbit kidney proximal tubule cells. By measuring the formation of [$^3H$] phosphatidic acid and [$^3H$]diacylglycerol. This result suggests that some phosphatidic acid seems to be formed directly from phosphatidylcholin by the action of phopholipase D, not from the action of diacylglycerol kinase on the diacylglycerol. In addition the other mechanisms by which phospholipase D is activated was examined. We have found that phospholipase D was activited by extracellular calium ion. It has also been shown that angiotensin II may activate phosphoilpase D through protein kinase C-independent pathway.

Keywords

References

  1. Methods in Enzymology v.141 Measurement of inositol phospholipid metabolism by one-dimentional thin-layer chromatography Andrews,W.V.;Conn,P.M.;Means,A.R.(ed.);Conn,P.M.(ed.)
  2. Biochem. J. v.269 The regulation and celluar functions of phosphatidylcholine hydrolysis Billah,M.M;Anthes,J.C.
  3. J. Biol. Chem. v.264 Regulation of phospholipase D in HL-60 granulocytes Billah,M.M.;Pai,J.K.;Mullman,T.J.;Egan,R.W.;Siegel,M.I.
  4. Can. J. Biochem. Physioil. v.37 A rapid method of total lipid extraction and purification Bligh,E.A.;Dyer,W.J.
  5. Tips. v.15 A role for phospholipase D in control of mitogenesis Boarder,M.R.
  6. Biochem. J. v.264 Phospholipase D activation is functionally linked to superosxide generation in the human neutrophil Bonser,R.W.;Thompson,N.T.;Randall,R.W.;Tateson,G.D.;Garland,L.G.
  7. Br. J. phamacol. v.103 Demethoxyviridin and wortmannin block phospholipase C and D activation in human neutrophil Bonser,R.W.;Thompson,N.T.;Randall,R.W.;Tateson,G.D.;Spacey,G.D.;Hodson,H.F.;Garland,L.G.
  8. J. Cell Biol. v.95 Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium Chung,S.D.;Alavi,N.;Livingston,D.;Hiller,S.;Taub,M.
  9. Tips. v.14 Signalling properties of lysophoshatidic acid Durieux,M.E.;Lynch,K.R.
  10. J. Biol. Chem. v.265 no.1 Signaling through phosphatidylcholine breakdown Exton,J.H.
  11. J. Biol. Chem. v.263 Generation of inositol phosphtes,cytosolic ca+² , and ionic fluxes in PC12 cells treated with bradykinin Fasolato,C.;Pandiella,A.;Meldolesi,J.;Pozzan,T.
  12. Biochem. J. v.299 Angiotesin Ⅱstimulates phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular smooth-muscle cells Gadiparthi,N.R.;Lassegue,B.;Alexander,R.W.;Griendling,K.K.
  13. J. Biol. Chem. v.262 Correlation of receptor sequestration with sustained diacylglycerol acumulation in angiotensin Ⅱ-stimulated cultured vascular smooth muscle cells Griendling,K.K.;Delafontaine,P.;Rittenhouse,S.E.;Gimbrone,M.A.;Alexander,R.W.
  14. Biochem. J. v.276 AngiotensinⅡ-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells Griendling,K.K.;Lassegue,B.;Alexader,R.W;Clark,M
  15. J. Immunol. v.144 An indirect pathway of receptor-mediated 1,2-diacylgly-cerol formation in mast cells Gruchalla,R.S.;Dinh,T.T.;Kennerly,D.A.
  16. J. Neurochem. v.59 Pertusis toxin-insensitive G Protein mediates carbachol activation of phospholipase D in rat pheochromocytoma PC12 cells Hiroyuki,K.;Yasunori,K.;Yoshinori,N.
  17. J. Neurochem. v.56 Bradykinin activates a phospholipse D that hydrolyzes phosphatidylcholine in PC12 cells Horwitz,J.
  18. J. Neurochem. v.54 Carbachol and bradykinin increase the production of diacylglycerol from inositol-containing phospholipids in PC12 cells Horwitz,J.
  19. J. Neurochem. v.59 Bradykinin and phorbol dibutyrate activate phospholipase D in PC12 cells by different mechanisms Horwitz,J.;Ricanati,S.
  20. J. Biol. Chem. v.265 Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types Huang,C.;Cabot,M.C.
  21. J. Neurochem. v.48 Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D Kobayashi,M.;Kanfer,J.N.
  22. J. Biol. Chem. v.264 Phosphatidylethanol biosynthesis in ethanol-exposed NG 108-15 neuroblastoma x glioma hybrid cells Liscovitch,M.
  23. J. Biol. Chem. v.264 Gonadotropn-releasing hormone activates phospholipase D in ovarian granulosa cells. Liscovitch,M.;Amsterdam,A.
  24. Nature v.323 Growth factor like action phosphatidic acid Moolenaar,W.H.;Kruijer,W.;Tilly,B.C.;Verlaan,I.;Bierman,A.J.;De Laat,S.W.
  25. J. Biol. Chem. v.263 Phospholipase D catalyzes phospholipid metabolism in chemotactic petide-stimulated HL-60 granulocytes Pai,J.K.;Siegel,M.I.;Egan,R.W.;Billah,M.M.
  26. FASEB. v.4 Activation of human neutrophil phospholipase D by three separable mechanisms Reinhold,S.L.;Prescott,S.M.;Zimmerman,G.A.;Mclntyre,T.M.
  27. Biochem. Biophys. Res. Coummn. v.135 Staurosporine, a potent inhibitor of phospholipid/ca+² dependent protein kinase Tamaoki,T.;Nomoto,H.;Takahashi,I.;Kato,Y.;Morimoto,M.;Tomita,F.
  28. Tips. v.12 Receptor-coupled phospholipase D and its inhibition Thompson,N.J.;Bonser,R.W.;Garland,L.G.
  29. J. Neurochem. v.39 Alteration of lipid metabolim in response to nerve growth factor Traynor,A.E.;Schuber,D.;Alled,W.R.
  30. J. Biol. Chem. v.266 Existence of cytosolic phospholipase D Wang,P.;Anthes,J.C.;Siegel,M.I.;Egan,R.W.;Bilah,M.M.