Archives of Pharmacal Research
- Volume 17 Issue 5
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- Pages.364-370
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Prediction of drug-Drug Interaction During Oral Absorption of Carrier-Mediated Compounds in Humans
- Oh, Doo-Man (College of Pharmacy, Hyosung Womens University) ;
- Gordon L. Amidon (College of Pharmacy, The University of Michigan)
- Published : 1994.10.01
Abstract
A microscopic mass balance approach has been developed to estimate the extent and rate of absorption for camier-mediated comounds. For the case competitive inhibition in the presence of an inhibitor which shares the same camier, the fraction dose absorbed (F) and absorption rate constant (