Archives of Pharmacal Research
- Volume 17 Issue 5
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- Pages.327-330
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
A Regioselectio Synthesis of ${\beta}-Lactones$ ; Bromolactonization of 2-Substituted-1-Cyclohexenyl-1-acetic acid
- Jew, Snag-Sup (College of Pharmacy, Seoul National University) ;
-
Lee, Hee-Soon
(College of Pharmacy, Chungbuk National University)
;
- Koo, Bon-Am (College of Pharmacy, Seoul National University)
- Published : 1994.10.01
Abstract
Bromolactonization of 2-substituted-1-cyclohexenyl-1-acetic acids with 1, 3-dibromo-5, 5-dime-thylhydantoin 9DBH) and potsssium tertiary butoxide (t-BuOK0 in anhydrous DMF was found to proceed in a highly regioselective manner. The reaction predominantly resulted in the formation of